Jeffrey Wolf, MD, on Findings From a Study Investigating Therapy Changes Using MRD in Patients With Multiple Myeloma

Video

Wolf discussed the decisions to change therapy based on the MRD status of patients with multiple myeloma.

Jeffrey Wolf, MD, of the University of California San Francisco, discussed with CancerNetwork® the results from his presentation “Making Clinical Decisions to Change Therapy Using Measurable Residual Disease Improves the Outcome in Multiple Myeloma” at the 2020 American Society of Hematology (ASH) Annual Meeting & Exposition.

Transcription:

What we did in this study is we looked at 373 patients, both in San Francisco and in Spain. In 58 cases, we found that we had to change our therapy because of what we discovered. In some cases, it was because the patient had 0 malignant cells that we could measure for MRD; and in 3 cases, we decided not to even take them to a bone marrow transplant, which is sort of standard, because we felt we had gotten a deep enough response. In other cases, we found 0 malignant cells out of a million and decided that we could stop the maintenance therapy they were on. In still others, we found that by measuring [the MRD] sequentially, we could say that the therapy they were on wasn’t effective and either stop it or stop it and initiate some other therapy that could result in a better, lower MRD.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
An ongoing phase 1 trial seeks to prove XmAb819 as an effective treatment and ENPP3 as a plausible target in patients with relapsed or refractory RCC.
“The therapy is designed to prevent both CAR T-cell inactivation and to restore the anti-tumor immunity of the white blood cells that have gotten through the tumor,” said Marasco, MD, PhD.
Ongoing studies aim to combine base immunotherapy regimens with novel agents to potentially improve outcomes among patients with kidney cancer.
Investigators have found a way to reduce liver and biliary toxicity when targeting the molecule CAIX in patients with clear cell renal cell carcinoma.
Neoantigen-targeting vaccines resulted in an absence of recurrence in 9 patients with high-risk kidney cancer, according to David A. Braun, MD, PhD.
The Kidney Cancer Research Consortium may allow collaborators to form more mechanistic and scientifically driven efforts in the field.
Wayne A. Marasco, MD, PhD, stated that by targeting 2 molecules instead of 1, higher levels of tumor cell killing can be achieved in patients with clear cell renal cell carcinoma.
Leading experts in the breast cancer field highlight the use of CDK4/6 inhibitors, antibody-drug conjugates, and other treatment modalities.
Related Content