Jeffrey Wolf, MD, on Findings From a Study Investigating Therapy Changes Using MRD in Patients With Multiple Myeloma

Wolf discussed the decisions to change therapy based on the MRD status of patients with multiple myeloma.

Jeffrey Wolf, MD, of the University of California San Francisco, discussed with CancerNetwork® the results from his presentation “Making Clinical Decisions to Change Therapy Using Measurable Residual Disease Improves the Outcome in Multiple Myeloma” at the 2020 American Society of Hematology (ASH) Annual Meeting & Exposition.


What we did in this study is we looked at 373 patients, both in San Francisco and in Spain. In 58 cases, we found that we had to change our therapy because of what we discovered. In some cases, it was because the patient had 0 malignant cells that we could measure for MRD; and in 3 cases, we decided not to even take them to a bone marrow transplant, which is sort of standard, because we felt we had gotten a deep enough response. In other cases, we found 0 malignant cells out of a million and decided that we could stop the maintenance therapy they were on. In still others, we found that by measuring [the MRD] sequentially, we could say that the therapy they were on wasn’t effective and either stop it or stop it and initiate some other therapy that could result in a better, lower MRD.

Related Videos
Early data from ongoing clinical trials suggest the potential safety and efficacy of novel radium-223 combinations as treatment for metastatic castration-resistant prostate cancer.
Noa Biran, MD, an expert on multiple myeloma
Experts on multiple myeloma
An expert from Dana-Farber Cancer Institute discusses findings from the final overall survival analysis of the phase 3 ENGOT-OV16/NOVA trial.
The use of palliative care in ovarian cancer resulted in a decrease in overall readmissions and index hospitalization costs.
Current clinical trials look to assess 177Lu-PSMA-617 in combination with other therapies including androgen deprivation therapy and docetaxel.
An expert from Dana-Farber Cancer Institute indicates that patients with prostate cancer who have 1 risk factor should undergo salvage radiotherapy following radical prostatectomy before their prostate-specific antigen level rises above 0.25 ng/ml.
Experts on multiple myeloma
Experts on multiple myeloma
Related Content