Philippe Moreau, MD, on Updates in Multiple Myeloma Presented at ASCO 2021

Video

Moreau highlighted important updates in the field of multiple myeloma, including the CARTITUDE-1 trial, which yielded promising results with ciltacabtagene autoleucel and read out at the 2021 ASCO Annual Meeting.

Philippe Moreau, MD, of the University Hospital of Nantes, who presented data from part 2 of the phase 3 CASSIOPEIA trial (NCT02541383),1 spoke with CancerNetwork® at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, regarding recent research in the field of multiple myeloma that may have a notable impact on the treatment paradigm. In particular, the phase 1b/2 CARTITUDE-1 trial (NCT03548207), which investigated the use of ciltacabtagene autoleucel (cilta-cel) in relapsed/refractory multiple myeloma, had promising results, according to Moreau.2

Transcription:

At ASCO, we have [had] very important trials and very important results, especially for advanced patients. We have heard about the results of the CARTITUDE-1 trial, the updated analysis of the CAR T-cell therapy [cilta-cel from Janssen. The results seem really great in patients who are triple class refractory with a median progression-free survival that was not yet reached. [These were] very encouraging results. [There was] also a data analysis of bispecifics, such as teclistamab and talquetamab [JNJ-64407564] that was also very promising.

Reference

1. Moreau P, Sonneveld P. Daratumumab (DARA) maintenance or observation (OBS) after treatment with bortezomib, thalidomide and dexamethasone (VTd) with or without DARA and autologous stem cell transplant (ASCT) in patients (pts) with newly diagnosed multiple myeloma (NDMM): CASSIOPEIA Part 2. J Clin Oncol 39, 2021 (suppl 15):8004. doi:10.1200/JCO.2021.39.15_suppl.8004

2. Usmani SZ, Berdeja JG, Madduri D, et al. Ciltacabtagene autoleucel, a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed/refractory multiple myeloma (R/R MM): Updated results from CARTITUDE-1. J Clin Oncol. 2021;39(suppl 15):8005. doi:10.1200/JCO.2021.39.15_suppl.8005

Related Videos
Investigators must continue to explore the space for lisocabtagene maraleucel in mantle cell lymphoma, according to Manali Kamdar, MD.
Those with CML should discuss adverse effects such as nausea or fatigue with their providers to help optimize their quality of life during treatment.
A panel of 4 experts on multiple myeloma
A panel of 4 experts on multiple myeloma
Patients with CML can become an active part of their treatment plan by discussing any questions that come to mind with their providers.
A panel of 4 experts on multiple myeloma
Video 1 - 4 KOLs are featured in "Treating Patients Referred to Academic Centers for CAR T"
Video 1 - 4 KOLs are featured in "Identifying Potential Candidates for CAR T-Cell Therapy"
Beth Faiman, CNP, PhD, an expert on multiple myeloma
Jorge E. Cortes, MD, emphasizes proper communication between patients with chronic myeloid leukemia and their providers during the treatment course.
Related Content