Precision Active Surveillance: Leveraging Genomic Testing and CCR Scores in Prostate Cancer Management

EP: 1.Prolaris and Beyond: How Genomic Testing Has Revolutionized Prostate Cancer Management and Treatment Decisions

EP: 2.Using Genetic Information to Guide Precision Medicine and Personalized Treatment in Prostate Cancer: Expert Perspectives on an Evolving Landscape

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EP: 3.Precision Active Surveillance: Leveraging Genomic Testing and CCR Scores in Prostate Cancer Management

EP: 4.CCR Scores and Beyond: Precision Strategies for Treatment Intensification in Prostate Cancer

EP: 5.Prolaris in Practice: Guiding ADT Benefits, Clinical Application, and Expert Insights From ACRO 2025

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Genomic Testing in Prostate Cancer Active Surveillance

Key Considerations for Patient Selection

Expanded Risk Stratification

Traditional clinical parameters are now augmented by genomic testing, providing a more nuanced approach to active surveillance patient selection. Genomic panels such as Prolaris offer critical insights that extend beyond conventional risk factors, allowing for:

• More precise risk assessment
• Personalized treatment decision-making
• Reduction of unnecessary interventions

Reconciling Discordant Results

When genomic testing results differ from conventional clinical parameters:

• Prioritize comprehensive molecular risk assessment
• Establish clear genomic score thresholds for surveillance confidence
• Conduct thorough patient counseling about potential risks and benefits
• Consider additional diagnostic information (repeat biopsy, advanced imaging)

Clinical Decision-Making Framework

Genomic Testing Integration

• Utilize molecular markers to refine risk stratification
• Look beyond traditional Gleason scores and prostate-specific antigen levels
• Incorporate genomic proliferation scores and genetic mutation analyses

Emerging Research Considerations

Anticipated developments in the next 5 years:

• Advanced multigene panel testing
• Integration of liquid biopsy techniques
• More sophisticated machine learning algorithms for risk prediction
• Potential for personalized treatment algorithms based on genetic profiling

Recommendations for Clinicians

• Stay updated on latest genomic testing technologies
• Develop multidisciplinary approach to interpretation
• Engage in continuous education about molecular diagnostics
• Implement flexible decision-making protocols that incorporate genomic insights

Critical Evaluation Criteria

Factors to consider when recommending active surveillance based on genomic testing:

• Molecular proliferation scores
• Genetic mutation profiles
• Concordance with traditional clinical parameters
• Patient-specific risk factors
• Potential for disease progression

Future Outlook

The integration of genomic testing represents a paradigm shift in prostate cancer management, moving toward truly personalized precision medicine.