Progen Industries to Conduct Phase I Trial of PI-88 and Docetaxel

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 11 No 7
Volume 11
Issue 7

BRISBANE, Australia-Progen Industries is conducting a phase I trial combining its cancer drug PI-88 with docetaxel (Taxotere) in patients with advanced malignancies. The trial is taking place at the University of Colorado Cancer Center,

BRISBANE, Australia—Progen Industries is conducting a phase I trial combining its cancer drug PI-88 with docetaxel (Taxotere) in patients with advanced malignancies. The trial is taking place at the University of Colorado Cancer Center, Denver, with Scott Holden, MD, as principal investigator, Progen said in a news release.

PI-88 is a semisynthetic sulfated oligosaccharide that has several modes of action. In animal models it has been shown to prevent angiogenesis by inhibiting fibroblast growth factor, and to block metastasis by inhibiting the enzyme heparinase, which allows cancer cells to escape blood vessels. It also stimulates sustained release of TFPI (tissue factor pathway inhibitor), a natural inhibitor of angiogenesis, from cells lining the blood vessel wall.

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
1 expert is featured in this series.
2 experts are featured in this series.
2 experts are featured in this series.
5 experts are featured in this series
5 experts are featured in this series
2 experts in this video
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
2 experts in this video
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
Related Content