Sara A. Hurvitz, MD, Discusses Outcomes With Sacituzumab Govitecan By Age for Metastatic Triple-Negative Breast Cancer

At the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, CancerNetwork® spoke with Sara A. Hurvitz, MD, from the University of California, Los Angeles Jonsson Comprehensive Cancer Center, about utilizing sacituzumab govitecan (Trodelvy) for the treatment of older patients with metastatic triple-negative breast cancer (mTNBC).

Sacituzumab govitecan was examined in the phase 3 ASCENT study (NCT02574455) in patients with relapsed/refractory TNBC with subgroup analyses performed to assess the impact of age. The study found that regardless of age (≥65 or <65 years), patients who had received 2 or more chemotherapies had a significant survival benefit with use of sacituzumab govitecan.

Transcript:

It’s quite important for us as clinical investigators to explore outcomes based on age. We do have an aging population and cancer is a disease that, at least in breast cancer, increases [with patients who are] increasing in age. It is really important for us to look at outcomes based on age. From a geriatrician standpoint, I think they would support this type of analysis because treatment decisions across the board—whether it’s in cardiology, pulmonology, oncology, or endocrinology—should be based on a patient’s performance status and ability to accept therapy rather than a numerical age. I’m reassured that these data show a similar efficacy outcome with the use of sacituzumab as well as a reasonable safety profile. The data will make us all more comfortable offering this therapy that’s associated with a survival benefit to patients, regardless of their age. I’m sure geriatric oncologists applaud this type of analysis.

Reference:

Kalinsky K, Oliveira M, Traina T, et al. Outcomes in patients (pts) aged ≥65 years in the phase 3 ASCENT study of Sacituzumab govitecan (SG) in metastatic triple negative breast cancer (mTNBC). J Clin Oncol. 2021;39(suppl 15):1011. doi: 10.1200/JCO.2021.39.15_suppl.1011