Suresh S. Ramalingam, MD, Discusses Adjuvant Therapy for Early NSCLC at 2021 ASCO

Video

During the 2021 ASCO Annual Meeting, Suresh S. Ramalingam, MD, looked forward to how trials regarding adjuvant therapy for early-stage non–small cell lung cancer are poised to change the treatment paradigm in this setting.

CancerNetwork® sat down with Suresh S. Ramalingam, MD, of the Winship Cancer Institute, Atlanta, Georgia, at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting to talk about a trial involving atezolizumab (Tecentriq) in early-stage non–small cell lung cancer. He said this and other trials involving adjuvant therapy have great potential for clinical impact in the early-disease setting.

Transcript:

I think the adjuvant trial with the atezolizumab in early-stage non–small cell lung cancer is an eagerly anticipated trial. There have been multiple randomized trials that have been completed using immune checkpoint inhibitors in resected non–small cell lung cancer. The IMpower010 [NCT02486718] study is the first one to report out at this year’s meeting, and I believe those results will be discussed and potentially integrated into practice. The notion that we could use immune checkpoint inhibitors in early-stage disease to improve overall outcomes is very exciting, and an important step forward in the management of early-stage lung cancer. We’ve used adjuvant chemotherapy for these patients for nearly 2 decades now, [and] more recently for EGFR-mutated [disease]. Osimertinib [Tagrisso] has gained approval for patients without these targetable mutations. Using immunotherapy would be another novel way to improve their outcomes. I’m very interested in excited about the adjuvant immunotherapy data.

Reference

Heather W, Nasser A, Caicun Z, et al. Impower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer. J Clin Oncol. 2021;39(suppl 15):8500. doi:10.1200/JCO.2021.39.15_suppl.8500

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
Success with the 177Lu-PSMA-617 radioligand therapy would be transformative for the clear cell renal cell carcinoma treatment landscape.
4 experts in this video
4 experts in this video
An ongoing phase 1 trial seeks to prove XmAb819 as an effective treatment and ENPP3 as a plausible target in patients with relapsed or refractory RCC.
“The therapy is designed to prevent both CAR T-cell inactivation and to restore the anti-tumor immunity of the white blood cells that have gotten through the tumor,” said Marasco, MD, PhD.
Ongoing studies aim to combine base immunotherapy regimens with novel agents to potentially improve outcomes among patients with kidney cancer.
Investigators have found a way to reduce liver and biliary toxicity when targeting the molecule CAIX in patients with clear cell renal cell carcinoma.
Neoantigen-targeting vaccines resulted in an absence of recurrence in 9 patients with high-risk kidney cancer, according to David A. Braun, MD, PhD.
The Kidney Cancer Research Consortium may allow collaborators to form more mechanistic and scientifically driven efforts in the field.
Wayne A. Marasco, MD, PhD, stated that by targeting 2 molecules instead of 1, higher levels of tumor cell killing can be achieved in patients with clear cell renal cell carcinoma.
Related Content