Zactima Gets Fast Track Status for Medullary Thyroid Cancer

March 1, 2006
Oncology NEWS International, Oncology NEWS International Vol 15 No 3, Volume 15, Issue 3

AstraZeneca, Zactima, ZD6474, medullary thyroid cancer

WILMINGTON, Delaware—AstraZeneca's Zactima (ZD6474) has received FDA fast track designation for the treatment of medullary thyroid cancer. Zactima, a once-daily oral agent, targets tumor cells through inhibition of EGFR and REarranged during Transfection (RET) tyrosine kinases, and tumor blood supply through inhibition of VEGFR tyrosine kinase. Zactima, which also has orphan drug status for medullary thyroid cancer, is currently being evaluated in a phase II clinical trial.