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Adjuvant therapy, almost by
definition, overtreats patients.
It is the holy grail of those of
us involved in adjuvant therapy to define
the patients who are going to fail
so that we can decrease the incidence
of tumor recurrence and avoid giving
additional therapy to patients who have
been cured by their primary treatment.
Adjuvant therapy, almost by
definition, overtreats patients.
It is the holy grail of those of
us involved in adjuvant therapy to define
the patients who are going to fail
so that we can decrease the incidence
of tumor recurrence and avoid giving
additional therapy to patients who have
been cured by their primary treatment.
The authors present a thorough review of the mechanisms and clinical effects of fluoropyrimidine radiation sensitization. As they discuss, abundant clinical data from multiple tumor sites show improved outcome when radiation is delivered in
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