Patient, Provider and Caregiver Connection™: Addressing Patient Concerns During the Treatment and Management of HR+/HER2- Breast Cancer
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Oncology Consultations®: Next Generation SERDs—Key Data and Practical Takeaways for the Community Physician
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Multidisciplinary Management of TNBC: Immunotherapy, PARP, TROP2, Oh My!
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Medical Crossfire®: Leveraging Multidisciplinary Teams in Early–Stage Breast Cancer When the Goal is Cure
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23rd Annual International Congress on the Future of Breast Cancer® East
July 19-20, 2024
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Community Practice Connections™: 14th Annual International Symposium on Ovarian Cancer and Other Gynecologic Malignancies
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Community Practice Connections™: The Advent of TROP2-Targeted Treatment Approaches in HR+/HER2- Breast Cancer
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Community Practice Connections™: Controversies and Conversations About HER2- Expressing Breast Cancer…Advances in Management of HER2-Low to -Positive Disease
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Show Me the Data™: Do We Have Sea Change for Novel Approaches in HR+/HER2- Breast Cancer? CDK, PI3K/AKT, ADC, and Next-Gen SERD Strategies Assessed
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Cancer Summaries and Commentaries™: Clinical Updates from Chicago in Breast Cancer
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42nd Annual CFS®: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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42nd Annual Miami Breast Cancer Conference®
March 6 - 9, 2025
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The Evolving Tool Box in Advanced HR+/HER2– Breast Cancer: What You Need to Know About Next-Generation SERDs, PI3K/AKT, ADCs, CDK4/6 and Beyond…
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Coffee Talk™: Navigating the Impact of HER2/3, TROP2, and PARP from Early Stage to Advanced Breast Cancer Care
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Fluorouracil-Based Combinations in the Treatment of Metastatic Breast Cancer
January 1st 1998Although combination chemotherapy regimens may prolong survival for selected patients with metastatic breast cancer, few, if any, are cured. The standard regimens used in treatment, eg, CMF (cyclophosphamide,
Dose-Dense Paclitaxel-Containing Adjuvant Therapy for Breast Cancer
January 1st 1998The use of dose-dense therapy is one approach to overcoming the “resistance” of malignant cells to adjuvant therapy caused by inadequate drug exposure. In this approach, active drugs are delivered sequentially at their “ideal” dose level separated by short intertreatment intervals. Thus, dose intensification is achieved by means of rapidly recycled treatments rather than by dramatic dose escalation. To overcome absolute cellular resistance, the addition of new, active, non-cross-resistant drugs holds great promise and has specifically motivated the testing of the taxanes. This article describes the results of clinical trials of dose-dense therapy, with particular emphasis on attempts to incorporate one taxane, paclitaxel (Taxol), into the dose-dense regimen of sequential doxorubicin and cyclophosphamide-the so-called A ® T ® C regimen, and into more conventional regimens.[ONCOLOGY 12(Suppl 1)16-18, 1998]
Paclitaxel and Carboplatin as First-Line Chemotherapy for Advanced Breast Cancer
In a phase II study, 66 patients with advanced breast cancer (median age 56 years; range, 28 to 75 years) were treated with paclitaxel (Taxol), 175 mg/m² infused over 3 hours, and carboplatin (Paraplatin), dosed to attain an
Taxanes in Adjuvant and Neoadjuvant Therapies for Breast Cancer
January 1st 1998Paclitaxel (Taxol) is a diterpene originally obtained from the bark of the Pacific Yew Tree, Taxus Brevifolia. Its mechanism of action is unique. it stabilizes microtubule polymerization, thus blocking cells in the G2/M phase of
Paclitaxel Plus Epirubicin in Advanced Breast Cancer
This phase I-II study aimed to determine the maximum tolerated dose (MTD) of paclitaxel (Taxol), infused over 3 hours, when combined with a fixed dose (90 mg/m²) of epirubicin. Other aims were to investigate the combination’s
One-Hour Paclitaxel via Weekly Infusion: Dose-Density With Enhanced Therapeutic Index
January 1st 1998A preliminary report of a phase II trial of paclitaxel (Taxol) administered in a dose-dense manner as first- and second-line therapy for metastatic breast cancer is presented. Patients who had received one or two prior
Komen Debuts New Websites on Breast Cancer
December 1st 1997DALLAS-The Susan G. Komen Breast Cancer Foundation, known for raising awareness and community support for breast cancer research and programs through its Race for the Cure, has unveiled three new websites that form a comprehensive online source of breast health and breast cancer information.
Survivors Help Women Deal With Breast Cancer Diagnosis
December 1st 1997NEW YORK-Two breast cancer survivors-one an oncologist from Albert Einstein College of Medicine, the other, the head of the National Alliance of Breast Cancer Organizations (NABCO)-were among those offering special perspectives at a public meeting on clinical and public policy issues related to breast cancer, sponsored by NABCO and held at Memorial Sloan-Kettering Cancer Center.
Few Absolute Contraindications to Breast Conservation
December 1st 1997CHICAGO-The clinical rationale for breast-conserving surgery has been unequivocally established by prospective, randomized clinical trials that show no difference in survival between this form of surgery and mastectomy. In many parts of the country, however, less than 50% of women with early-stage breast cancer are having breast-conserving surgery.
Phase III HER-2/neu MoAb Trial Results Due Next Year
December 1st 1997PHILADELPHIA-The anti-HER-2/neu monoclonal antibody is now in the final stages of phase III testing, in combination with an anthracycline, in patients with advanced breast cancer tumors that overexpress the gene product, Dennis Slamon, MD, of the UCLA School of Medicine, said at a breast cancer symposium at Fox Chase Cancer Center.
Combined-Modality Therapy for Head and Neck Cancer
December 1st 1997In 1970, Ansfield and colleagues published the results of a randomized trial in head and neck cancer, which showed that giving fluorouracil (5-FU) concomitantly with radiation decreased regional recurrences and improved overall survival over radiation alone.[1] Publication of these results came 6 years before those of an Italian trial showing similar findings with adjuvant cyclophosphamide, methotrexate, and 5-FU (CMF) in breast cancer.[2] Yet, while adjuvant chemotherapy has rapidly become the norm in the management of early breast cancer, concomitant chemotherapy is still considered undefined in the treatment of head and neck cancer. This situation is elegantly described by Dr. Karen Fu, one of the most respected investigators in this area.
Tumor Cells in Marrow Predict Cancer Outcome
November 1st 1997HAMBURG-Tumor cell detection (TCD) in bone marrow should supplant axillary lymph node status as a prognostic indicator for women with early breast cancer, Ingo J. Diel, MD, of the University of Heidelberg, said at the Ninth European Cancer Conference (ECCO 9).
Zeneca Sponsors Rural Breast Cancer Outreach
November 1st 1997CHICAGO-October’s National Breast Cancer Awareness Month (NBCAM) had a special focus on women in America’s agricultural communities. Zeneca, a founding co-sponsor of NBCAM, said that its breast cancer education program will target rural women to raise awareness of the need for mam-mography and other early detection methods in this population.
Sentinel Node Biopsy May Spare Breast Cancer Patients Axillary Node Dissection
November 1st 1997HAMBURG-In women with operable breast cancer of small size, sentinel node biopsy can be used to predict the status of the axillary lymph nodes and thereby avoid unnecessary axillary dissection, according to a report from the European Institute of Oncology in Milan presented at the Ninth European Cancer Conference (ECCO 9).
Dose-Dense Adjuvant Chemo for Node+ Breast Cancer
November 1st 1997ATLANTA-With dose-escalation studies of adjuvant chemotherapy in node-positive breast cancer producing mixed results, many researchers are moving to the dose-density approach, Clifford A. Hudis, MD, said at the Third Annual Perspectives in Breast Cancer meeting.
Estrogen Alternatives in Breast Cancer Patients
November 1st 1997WASHINGTON-A consensus conference convened to assess the treatment of estrogen deficiency symptoms in breast cancer survivors has recommended that physicians treat these women with “tailored treatment strategies” that avoid the use of estrogen but provide its short-term and long-term benefits.
Trial of Toremifene vs Tamoxifen as Adjuvant Breast Cancer Therapy
November 1st 1997SOUTHAMPTON, Bermuda-Shortly after the publication of trial results showing similar efficacy of antiestrogens toremifene (Fareston) and tamoxifen (Nolvadex) in metastatic breast cancer, the Finnish Breast Cancer Group started to plan a comparison study of the two agents as adjuvant breast cancer therapy, said Kaija Holli, MD, of Tampere University Central Hospital, Tampere, Finland.
New Directions for Breast Cancer Research: Piccart
November 1st 1997HAMBURG-“I can see at least three new directions that carry the potential for significant improvements in the care of breast cancer patients in the coming years,” said Dr. Martine Piccart, winner of the 1997 Hamilton Fairley Award of the European Society of Medical Oncology (ESMO) in her address at the Ninth European Cancer Conference (ECCO 9).
Anastrozole: A New Selective Nonsteroidal Aromatase Inhibitor
November 1st 1997Endocrine therapy has long been a mainstay in the therapy of metastatic breast cancer and in the adjuvant setting. The introduction of anastrozole (Arimidex) to the market in 1996 has provided another option for such treatment. Drs. Goss and Tye provide a thorough review of anastrozole and outline its advantages over other aromatase inhibitors as adjuvant therapy for breast cancer and its potential use in the treatment of early breast cancer. The authors delineate many important issues regarding the use of anastrozole; an understanding of these issues is imperative for the optimal utilization of this therapy. The paper has two shortcomings: (1) It focuses almost solely on aromatase inhibitors, to the neglect of other endocrine therapies. (2) Many references are unconventional and represent data on file with various drug manufacturers, which are not easily accessible to readers.
Clinical Status and Optimal Use of the Cardioprotectant, Dexrazoxane
November 1st 1997Anthracycline antibiotic use is limited by cardiac toxicity. The risk factors are cumulative dose, radiation to the chest and mediastinum, age, and preexisting myocardial impairment. Dexrazoxane (Zinecard) can prevent
Anastrozole: A New Selective Nonsteroidal Aromatase Inhibitor
November 1st 1997Aromatase (estrogen synthetase) is the enzyme complex responsible for the final step in estrogen synthesis-the conversion of androstenedione and testosterone to estrone and estradiol, respectively. Inhibitors of this enzyme
Adriamycin Bests Taxol as Therapy for Advanced Breast Cancer
November 1st 1997HAMBURG-In previously un-treated women with advanced breast cancer, doxorubicin (Adriamycin) yields a higher response rate and longer progression-free survival than does paclitaxel (Taxol), according to the results of a randomized crossover trial conducted by the EORTC and presented at the Ninth European Cancer Conference (ECCO 9).
Safety Data From North American Trials of Vinorelbine
October 2nd 1997Data from North American clinical trials have shown that vinorelbine (Navelbine) is well tolerated when used as a single agent for the treatment of non-small-cell lung cancer, advanced breast cancer, or ovarian cancer. Myelosuppression is the primary dose-limiting toxicity.
Toremifene, Tamoxifen Equivalent in Advanced Breast Cancer
October 1st 1997SOUTHAMPTON PRINCESS, Bermuda-Three large randomized studies comparing the antiestrogens toremifene (Fareston) and tamoxifen (Nolvadex) in patients with advanced breast cancer showed no significant differences in efficacy or toxicity, Richard A. Gams, MD, of the James Cancer Hospital, Ohio State University, said at a symposium on antiestrogen therapy for breast cancer sponsored by Schering.