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Breast Cancer

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TAMPA, Fla-Anecdotal reports suggest that the selective serotonin-reuptake inhibitors (SSRIs) commonly prescribed for depression might be efficacious in alleviating hot flashes in breast cancer survivors without the risks associated with hormonal therapies. Vered Stearns, MD, of the Lombardi Cancer Center, Georgetown University Medical Center, discussed her research at the American Cancer Society’s 42nd Annual Science Writers Seminar.

WASHINGTON-A survey has found that breast cancer researchers largely support legislation to “minimize the risk of exploitation of medical information by commercial sources and otherwise adequately protect patient privacy.” However, they also are concerned about “unbridled privacy laws” that would “delay or discourage scientific progress through quality research.”

CHICAGO-Breast conservation followed by radiotherapy is an effective treatment approach for invasive breast cancer in medically indigent black women, but prompt initiation of the radiotherapy and adequate radiation dose are necessary to achieve optimal results, according to a study presented at the 85th Annual Meeting of the Radiological Society of North America (RSNA).

SAN DIEGO-Hormone replacement therapy (HRT) did not shorten survival in women who received it after surviving breast cancer, Wendy R. Brewster, MD, reported in a plenary presentation at the 31st annual meeting of the Society of Gynecologic Oncologists (SGO).

ORLANDO-“Adjuvant therapy for breast cancer can be improved through the use of new agents, such as taxanes,” Edith A. Perez, MD, said at the Joint Cancer Conference of the Florida Universities. Dr. Perez is associate professor of medicine, Mayo Medical School, and director of the Clinical Investigation & Breast Cancer Program, Mayo Clinic, Jacksonville, Florida.

Women treated with tamoxifen (Nolvadex) had a 13% higher risk of disease progression than those treated with anastrozole (Arimidex), according to the North American and the European Tamoxifen or Arimidex Randomized Group Efficacy and

DALLAS-A new blood test technique to detect breast cancer cells may be 10- to 100-fold more sensitive than any current techniques, Jonathan W. Uhr, MD, of the University of Texas Southwestern Medical Center, Dallas, said at the Susan G. Komen Foundation’s National Grant Conference.

SAN ANTONIO-A computerized palpation device might offer an objective complement to clinical breast examination for detection of suspicious lumps, according to findings reported at the 22nd Annual San Antonio Breast Cancer Symposium. Lesion size as determined by the computerized palpation device better correlated with the palpable extent of the excised lesion than did size as determined by ultrasound, mammography, or clinical breast examination.

CHICAGO-In a screening program for young women with a high susceptibility for developing breast cancer, magnetic resonance imaging (MRI) proved more effective than mammography or ultrasound in detecting cancers, German researchers reported at the 85th Annual Meeting of the Radiological Society of North America (RSNA).

DALLAS-The antitumor powers of a venom protein from the southern copperhead snake are being studied at the University of Southern California. Results of early studies suggest that the protein, contortrostatin (CN), combines antagonism of breast cancer progression and inhibition of angiogenesis, making it a unique agent for control of breast cancer growth and proliferation.

For many oncologists and their patients with metastatic breast cancer, these are quite confusing times. A growing body of evidence suggests that pure dose-escalation strategies of high-dose chemotherapy with stem-cell support are unlikely to provide much additional benefit in patients with advanced breast cancer.[1] In fact, selection bias may explain much of the potential benefit seen in so many single-arm high-dose chemotherapy studies.[2]

FORT LAUDERDALE, Fla-The 17 institutions of the National Comprehensive Cancer Network (NCCN) are adhering closely to their own practice guidelines for breast cancer, according to a report given by the NCCN Outcomes Committee.

CHICAGO-Magnetic resonance imaging (MRI) was able to find tumors in two thirds of 47 patients with stage II or III occult primary breast cancer with a high degree of sensitivity, avoiding mastectomy in nearly half of the women, Elizabeth Morris, MD, reported at the 85th Annual Meeting of the Radiological Society of North America (RSNA).

ROME-The Susan G. Komen Breast Cancer Foundation has extended its breast cancer awareness programs internationally with the establishment of affiliates in Italy, Argentina, Germany, and Greece. The Dallas-based foundation has 117 local US affiliates.

ROME-A panel of cancer experts has called upon clinicians to do more to inform and counsel their patients about clinical trials. The plea was voiced during a webcast discussion sponsored by the Susan G. Komen Breast Cancer Foundation and held at the 5th Annual Multidisciplinary Symposium on Breast Diseases.

n DALLAS-A vaccine for breast cancer patients using fusions of dendritic cells and cancer cells is currently in phase I clinical testing, said Jianlin Gong, MD, Division of Cancer Pharmacology, Dana-Farber Cancer Institute, and instructor in medicine, Harvard Medical School.

FORT LAUDERDALE, Fla-The National Comprehensive Cancer Center (NCCN) Practice Guidelines for Breast Cancer have been updated to reflect the results of new trials demonstrating the effectiveness of tamoxifen (Nolvadex) as a risk reduction agent for women treated for breast cancer.