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ROME-The Susan G. Komen Breast Cancer Foundation has extended its breast cancer awareness programs internationally with the establishment of affiliates in Italy, Argentina, Germany, and Greece. The Dallas-based foundation has 117 local US affiliates.

ROME-A panel of cancer experts has called upon clinicians to do more to inform and counsel their patients about clinical trials. The plea was voiced during a webcast discussion sponsored by the Susan G. Komen Breast Cancer Foundation and held at the 5th Annual Multidisciplinary Symposium on Breast Diseases.

n DALLAS-A vaccine for breast cancer patients using fusions of dendritic cells and cancer cells is currently in phase I clinical testing, said Jianlin Gong, MD, Division of Cancer Pharmacology, Dana-Farber Cancer Institute, and instructor in medicine, Harvard Medical School.

FORT LAUDERDALE, Fla-The National Comprehensive Cancer Center (NCCN) Practice Guidelines for Breast Cancer have been updated to reflect the results of new trials demonstrating the effectiveness of tamoxifen (Nolvadex) as a risk reduction agent for women treated for breast cancer.

In an admirably concise fashion, Dr.Pritchard summarizes the results of trials randomizing tens of thousands of women in order to evaluate various types and uses of endocrine treatment over more than 50 years. I would never have predicted these results

Endocrine therapy is the oldest form of treatment for metastatic breast cancer. The availability of numerous new endocrine agents during the past 10 years has led to significant changes in the use of this form of therapy. This article identifies

There is no clear consensus among oncologists about the degree to which elderly breast cancer patients should be subjected to aggressive diagnostic and therapeutic strategies. Physicians consequently have tended to treat elderly women

SAN ANTONIO-Measurement of radiowave absorption could offer a new noninvasive approach to the identification and diagnosis of breast cancer, investigators involved in an ongoing evaluation of the technology reported at the 22nd Annual San Antonio Breast Cancer Symposium.

Breast-conserving treatment of early-stage breast cancer confers a low risk of locoregional recurrence that does not adversely affect survival, but early local recurrence increases the likelihood of metastatic disease, M.D.

VIENNA, Austria-Women with monthly breast pain appear to have a reduced risk of breast cancer, S. A. Khan and colleagues reported at a poster session of the 9th World Congress on Pain. The study also showed that women with a high consumption of dairy products had less severe pain and that regular consumption of soy products appeared to increase the likelihood of regular breast pain. Dr. Khan is in the Departments of Surgery, State University of New York Health Science Center, Syracuse.

ABERDEEN, Scotland-Primary, or neoadjuvant, chemotherapy with docetaxel (Taxotere) substantially increases the response rate in breast cancer patients who have received initial treatment with a chemotherapy combination, results of a phase III Scottish study demonstrate.

NOTTINGHAM, England-A new long-acting nonagonist antiestrogen, fulvestrant (Faslodex), significantly reduced estrogen and proges-terone receptor (ER/PR) content in breast tumors prior to surgery, compared with tamoxifen (Nolvadex) and placebo, according to a multicenter study presented at the San Antonio Breast Cancer Symposium.

BALTIMORE-Axillary lymph node status and hormone receptor status are significant prognostic factors in elderly breast cancer patients, warranting more careful consideration of lymph node dissection and adjuvant therapy, according to a review of 277 cases presented at the San Antonio Breast Cancer Symposium.

HAMBURG, germany-Elevated levels of two related tumor-associated proteases correlated with an increased risk of recurrence after definitive surgical treatment for node-negative breast cancer, German investigators reported at the San Antonio Breast Cancer Symposium.

BOSTON-The combination of weekly trastuzumab (Herceptin) and vinorelbine (Navelbine) gave promising results in a phase II study of metastatic breast cancer. After a median of 21 weekly courses of therapy, the combination has produced a 71% overall response rate (all partial responses) in 34 evaluable patients. The regimen has been well tolerated, and no patient has experienced symptomatic congestive heart failure.