ONCOLOGY Vol 9 No 8 | Oncology

Sociobiology and Cervical Cancer

August 01, 1995

The April 1995 issue of Oncology featured an article that presented sound information on the state of viral interactions and cervical cancer, along with several excellent reviews. Cancer of the uterine cervix is a significant health and emotional

Book Review: Cambridge Medical Reviews--Haematologic Oncology, Volume 3

August 01, 1995

Volume 3 of Cambridge Medical Reviews: Haematologic Oncology provides detailed reviews on 10 topics of current interest in the field of hematologic malignancies. The text is organized into 10 chapters and has 22 contributors.

Commentary (Moulin): Diagnosis and Management of Brachial Plexus Lesions in Cancer Patients

August 01, 1995

The signs and symptoms of brachial plexopathy are commonly seen in patients with cancer and pose a formidable management challenge. Tumor infiltration and radiation injury to the brachial plexus are the most common causes, and the distinction between the two has obvious prognostic and therapeutic implications. Dr. Kori reviews the clinical features and treatment options for each of these clinical entities and attempts to define the criteria that differentiate them.

Commentary (Kinsella): Current Status of Radiation Sensitization by Fluoropyrimidines

August 01, 1995

Drs. Pu, Robertson, and Lawrence provide a concise update of recent laboratory and clinical studies of fluoropyrimidine radiosensitization. From a clinical perspective, one can conclude that this drug-radiation interaction appears to be greater than additive and clearly has resulted in significant therapeutic gains, particularly for gastrointestinal cancers, as summarized in Tables 2 and 3 of their article. From a laboratory perspective, the focus has now shifted to trying to better understand the mechanisms of the interaction as related to molecular events at the G1/S interphase and in early S phase.

Commentary (Pritchard): Current Status of Vinorelbine For Breast Cancer

August 01, 1995

Dr. Smith's excellent article summarizes the preclinical and clinical data obtained to date on the role of vinorelbine (Navelbine) in women with breast cancer. Introducing a new agent into the arena of breast cancer is fraught with logistic

Diagnosis and Management of Brachial Plexus Lesions in Cancer Patients

August 01, 1995

Brachial plexus dysfunction is a well-known complication of cancer. Metastatic brachial plexopathy (MBP) and radiation injury to the brachial plexus (RBP) are the most common causes. The distinction between MBP and

Current Status of Vinorelbine For Breast Cancer

August 01, 1995

Vinorelbine tartrate (Navelbine) is a new semisynthetic vinca alkaloid with efficacy against a variety of solid tumors, including non-small-cell lung cancer, breast cancer, head and neck cancer, and Hodgkin's lymphoma.

Commentary (Rich): Current Status of Radiation Sensitization by Fluoropyrimidines

August 01, 1995

Fluorouracil has been used in combination with radiotherapy for the treatment of several malignant tumors with considerable success. In this excellent review, the authors point out that considerable gain could derive from increasing our understanding of the mechanisms of resistance of cytotoxicity or radiation enhancement.

Commentary (Blackstock/Tepper): Current Status of Radiation Sensitization by Fluoropyrimidines

August 01, 1995

The authors present a thorough review of the mechanisms and clinical effects of fluoropyrimidine radiation sensitization. As they discuss, abundant clinical data from multiple tumor sites show improved outcome when radiation is delivered in

Commentary (Fennelly): Current Status of Vinorelbine For Breast Cancer

August 01, 1995

This is a timely, comprehensive overview of the current status of vinorelbine (Navelbine) in the treatment of metastatic breast cancer. For most patients with advanced breast cancer, there is no clear evidence that chemotherapy prolongs survival, although it can achieve clear improvements in quality of life [1].

Current Status of Radiation Sensitization by Fluoropyrimidines

August 01, 1995

Numerous clinical studies suggest that the combination of the fluoropyridimine fluorouracil and radiation is a more effective treatment for many cancers, especially gastrointestinal tumors, than is either modality alone.