ONCOLOGY Vol 9 No 8

Even though they may be jeopardizing their future health, nearlyone quarter of women who find lumps or other possible breast cancer

The April 1995 issue of Oncology featured an article that presented sound information on the state of viral interactions and cervical cancer, along with several excellent reviews. Cancer of the uterine cervix is a significant health and emotional

Volume 3 of Cambridge Medical Reviews: Haematologic Oncology provides detailed reviews on 10 topics of current interest in the field of hematologic malignancies. The text is organized into 10 chapters and has 22 contributors.

The annual prevalence of cigarette smoking among adults in the United States declined 40% during 1965 to 1990 (from

The use of the anticancer agent vinorelbine (Navelbine) as a radiosensitizerto enhance the effectiveness of radiation treatment is suggested

Genetics Institute, Inc. announced positive results of a phaseII study of recombinant human interleukin-eleven (rhIL-11). In

Variations in structural proteins found in the nucleus of prostatecells may indicate whether a cell will become cancerous, according

A new minimally invasive surgery can provide better diagnosisand staging of cancer, according to a presentation at the 48th

Prostate cancer patients who have an elevated prostate-specific antigen (PSA) blood test after surgery need radiation therapy

The signs and symptoms of brachial plexopathy are commonly seen in patients with cancer and pose a formidable management challenge. Tumor infiltration and radiation injury to the brachial plexus are the most common causes, and the distinction between the two has obvious prognostic and therapeutic implications. Dr. Kori reviews the clinical features and treatment options for each of these clinical entities and attempts to define the criteria that differentiate them.

Drs. Pu, Robertson, and Lawrence provide a concise update of recent laboratory and clinical studies of fluoropyrimidine radiosensitization. From a clinical perspective, one can conclude that this drug-radiation interaction appears to be greater than additive and clearly has resulted in significant therapeutic gains, particularly for gastrointestinal cancers, as summarized in Tables 2 and 3 of their article. From a laboratory perspective, the focus has now shifted to trying to better understand the mechanisms of the interaction as related to molecular events at the G1/S interphase and in early S phase.

Dr. Smith's excellent article summarizes the preclinical and clinical data obtained to date on the role of vinorelbine (Navelbine) in women with breast cancer. Introducing a new agent into the arena of breast cancer is fraught with logistic

Brachial plexus dysfunction is a well-known complication of cancer. Metastatic brachial plexopathy (MBP) and radiation injury to the brachial plexus (RBP) are the most common causes. The distinction between MBP and

Vinorelbine tartrate (Navelbine) is a new semisynthetic vinca alkaloid with efficacy against a variety of solid tumors, including non-small-cell lung cancer, breast cancer, head and neck cancer, and Hodgkin's lymphoma.

Fluorouracil has been used in combination with radiotherapy for the treatment of several malignant tumors with considerable success. In this excellent review, the authors point out that considerable gain could derive from increasing our understanding of the mechanisms of resistance of cytotoxicity or radiation enhancement.

The authors present a thorough review of the mechanisms and clinical effects of fluoropyrimidine radiation sensitization. As they discuss, abundant clinical data from multiple tumor sites show improved outcome when radiation is delivered in

This is a timely, comprehensive overview of the current status of vinorelbine (Navelbine) in the treatment of metastatic breast cancer. For most patients with advanced breast cancer, there is no clear evidence that chemotherapy prolongs survival, although it can achieve clear improvements in quality of life [1].

Numerous clinical studies suggest that the combination of the fluoropyridimine fluorouracil and radiation is a more effective treatment for many cancers, especially gastrointestinal tumors, than is either modality alone.