Modulation of Dose Intensity in Aerodigestive Tract Cancers: Strategies to Reduce ToxicityDecember 1st 2001
Advances in diagnostic and therapeutic radiology and a better understanding of cell biology are being applied in practical ways to modulate treatment morbidity. Conformal radiotherapy targets the cancer precisely and can be combined with new systemically administered radiosensitizers.
Camptothecin Schedule and Timing of Administration With IrradiationMarch 2nd 2001
The camptothecins are a new class of chemotherapeutic radiation sensitizers. Clinical trials with camptothecins alone show higher toxicity than predicted by preclinical models, which has created the challenge of finding new
Camptothecin Radiation Sensitization: Mechanisms, Schedules, and TimingAugust 1st 1998
Based on high tumoricidal activity of the camptothecin analogs topotecan (Hycamtin), irinotecan (CPT-11[Camptosar]), and 9-aminocamptothecin (9-AC) in preclinical studies, clinical trials began testing these agents
Infusional Chemoradiation for Operable Rectal Cancer: Post-, Pre-, or Nonoperative Management?March 1st 1997
The use of adjuvant irradiation combined with systemic chemotherapy, or "chemoradiation," in the management of patients with operable rectal cancer has enabled more conservative surgery to be performed. Chemoradiation
Commentary (Rich): Current Status of Radiation Sensitization by FluoropyrimidinesAugust 1st 1995
Fluorouracil has been used in combination with radiotherapy for the treatment of several malignant tumors with considerable success. In this excellent review, the authors point out that considerable gain could derive from increasing our understanding of the mechanisms of resistance of cytotoxicity or radiation enhancement.