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Your AI-Trained Oncology Knowledge Connection!

|Videos|October 19, 2022

Bispecific Antibodies in the Treatment of R/R MM

Author(s)Surbhi Sidana, MD, Larry Anderson, MD, Caitlin Costello, MD

An explanation of the mechanism of action of bispecific antibodies and their use in relapsed/refractory multiple myeloma treatment.

Episodes in this series

EP. 1 Choosing the Appropriate Induction Regimen in Transplant-Eligible NDMM

EP. 1 Choosing the Appropriate Induction Regimen in Transplant-Eligible NDMM

EP. 2 Minimal Residual Disease-Response Adapted Therapy in Transplant-Eligible NDMM

EP. 2 Minimal Residual Disease-Response Adapted Therapy in Transplant-Eligible NDMM

EP. 3 Determining the Right Patients with NDMM for Autologous Stem Cell Transplant

EP. 3 Determining the Right Patients with NDMM for Autologous Stem Cell Transplant

EP. 4 Duration of Therapy and Maintenance Treatment in Transplant-Eligible NDMM

EP. 4 Duration of Therapy and Maintenance Treatment in Transplant-Eligible NDMM

EP. 5 Treating Patients with High-Risk NDMM

EP. 5 Treating Patients with High-Risk NDMM

EP. 6 Factors to Consider for Frontline Treatment of Transplant-Ineligible MM

EP. 6 Factors to Consider for Frontline Treatment of Transplant-Ineligible MM

EP. 7 Transplant-Ineligible Multiple Myeloma: The MAIA and SWOG 0777 Trials

EP. 7 Transplant-Ineligible Multiple Myeloma: The MAIA and SWOG 0777 Trials

EP. 8 Transplant-Ineligible Multiple Myeloma: The ENDURANCE Study

EP. 8 Transplant-Ineligible Multiple Myeloma: The ENDURANCE Study

EP. 9 Role of Triplet Therapy in Frail Patients with Transplant-Ineligible NDMM

EP. 9 Role of Triplet Therapy in Frail Patients with Transplant-Ineligible NDMM

EP. 10 Maintenance Therapy in Transplant-Ineligible NDMM

EP. 10 Maintenance Therapy in Transplant-Ineligible NDMM

$EP. 11 Available Treatment Options for Relapsed/Refractory Multiple Myeloma$

EP. 11 Available Treatment Options for Relapsed/Refractory Multiple Myeloma

EP. 12 Bispecific Antibodies in the Treatment of R/R MM

EP. 12 Bispecific Antibodies in the Treatment of R/R MM

EP. 13 CAR-T Therapy in R/R MM Treatment

EP. 13 CAR-T Therapy in R/R MM Treatment

EP. 14 Choosing a Bispecific Antibody for Treatment of R/R MM After Prior BCMA Therapy

EP. 14 Choosing a Bispecific Antibody for Treatment of R/R MM After Prior BCMA Therapy

EP. 15 Sequencing Therapies in Patients with R/R MM

EP. 15 Sequencing Therapies in Patients with R/R MM

EP. 16 Reflecting on Unmet Needs in Multiple Myeloma After IMS 2022

EP. 16 Reflecting on Unmet Needs in Multiple Myeloma After IMS 2022

Recap: Recent Advances in Multiple Myeloma From IMS 2022 and Beyond

EP. 17 Recap: Recent Advances in Multiple Myeloma From IMS 2022 and Beyond

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

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Daratumumab Combo Yields Significantly Higher MRD Negativity in Multiple Myeloma

ByONCOLOGY Staff

December 22nd 2025

$Data from a phase 1 trial may support additional clinical studies of CT0596 in relapsed/refractory multiple myeloma.$

Novel Anti-BCMA Agent Shows Preliminary Responses in R/R Multiple Myeloma

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Patients 70 years and older with newly diagnosed multiple myeloma experienced higher response rates and prolonged survival with Isa-Rd vs Rd alone.

Higher MRD Negativity Rates Occur With Isa-RD in Older NDMM Population

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Based on phase 1 data, GC012F/AZD0120 may broaden therapeutic options for patients with newly diagnosed multiple myeloma.

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The decision is based on results from the phase 3 MajesTEC-3 trial, which showed a PFS benefit with the teclistamab combination in patients with pretreated multiple myeloma.

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Rebecca Heist, MD, MPH; Alex A. Adjei, MD, PhD, FACP; Sandip Patel, MD, FASCO; Jeremy Segal, MD, PhD

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Medical Crossfire®: Improving Patient Outcomes in Myeloproliferative Neoplasms With Novel Therapeutic Approaches

Rami Komrokji, MD; Gabriela Hobbs, MD; John Mascarenhas, MD; Naveen Pemmaraju, MD

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Balazs Halmos, MD, MS; Enriqueta Felip, MD, PhD; Julia Rotow, MD

$Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma$

Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Vinay K. Puduvalli, MD; Manmeet Ahluwalia, MD, MBA; Stephen J. Bagley, MD, MSCE; Angela Waanders, MD, MPH, MS

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Gail J. Roboz, MD; Hagop Kantarjian, MD; Catherine Lai, MD, MPH; Amer Zeidan, MBBS, MHS

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

Jonathan W. Goldman, MD; Percy Lee, MD, FASTRO; Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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