Brian Rini, MD, on Key Practice Changing Abstracts in Prostate Cancer From 2021 ESMO

CancerNetwork® spoke with Brian Rini, MD, chief of clinical trials and professor of medicine at the Vanderbilt-Ingram Cancer Center, about intriguing abstracts presented at the 2021 European Society for Medical Oncology (ESMO) Congress. He mentioned a pair of abstracts in prostate cancer that will impact practice moving forward.

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In prostate cancer, there were 2 studies presented that will change practice. One was called PEACE-1 (NCT01957436), which looked at triplet therapy versus doublet therapy in prostate cancer. [The trial compared] 2 different hormonal agents plus chemotherapy versus just 1 hormone agent plus chemotherapy and showed a survival advantage that will absolutely impact practice. And then another in the rising PSA setting, looking at double hormone therapy versus single hormone therapy that also showed great results. I think those will immediately change practice.

Reference

Fizazi K, Charles Galceran J, Foulon S, et al. A phase III trial with a 2x2 factorial design in men with de novel metastatic castration-sensitive prostate cancer: overall survival with abiraterone acetate plus prednisone in PEACE-1. J Clin Oncol. 2021;39(no. 15_suppl):5000-5000. doi: 10.1200/JCO.2021.39.15_suppl.5000