|Articles|April 1, 1995

Oncology NEWS International

  • Oncology NEWS International Vol 4 No 4
  • Volume 4
  • Issue 4

Controlled-Release AZT Gets FDA Go-Ahead for New Drug Investigation

SAN DIEGO--Genta Jago, a joint venture between Genta Incorporated and Jagotec AG (Hergiswil, Switzerland), has filed an Investigational New Drug application with the FDA for a controlled-release formulation of zidovudine (AZT), marketed

SAN DIEGO--Genta Jago, a joint venture between Genta Incorporatedand Jagotec AG (Hergiswil, Switzerland), has filed an InvestigationalNew Drug application with the FDA for a controlled-release formulationof zidovudine (AZT), marketed by Burroughs Wellcome Co. as Retrovir.

The recommended dosage for AZT in the United States is six timesdaily. Results of pilot in vitro and human pharmacokinetic studiesin Europe suggest that once- or twice-daily dosing may be possiblewith the controlled-release formulation, which incorporates Jagotec'sGeomatrix delivery technology.

Articles in this issue

about 31 years ago

First Results of Avicidin Trials

about 31 years ago

Chemo Patients Often Develop Menstrual Irregularities

about 31 years ago

Growth Factor Receptor Blockade Moving From Laboratory to Clinic

about 31 years ago

Vinorelbine Plus Chemo Promising in Advanced Disease

about 31 years ago

Bone Substudy a Part of Tamoxifen Prevention Trial

about 31 years ago

Ultrasound Breast Screens Useful in Selected Women

about 31 years ago

New Roles Forecast for Endocrine Therapy

about 31 years ago

Antisense Drug Against BCL-2 Effective in Animal Cancer Models

about 31 years ago

Anticancer Drugs From Zeneca in Regulatory Phase of Development

about 31 years ago

Osteosarcoma Chemo Regimens Debated

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