A panel of expert oncologists consider treatment options for patients with NDMM that are transplant-ineligible.
Transcript:
Robert Z. Orlowski, MD: Let’s move on to transplant-ineligible patients. Cesar, give us an overview of some of the options for induction therapy.
Cesar Rodriguez, MD: There have been a lot of changes in terms of transplant-ineligible patients and how we’re going to manage these patients. We were used to doing melphalan for patients who weren’t going to go to transplant because we weren’t concerned about the ability to collect the stem cells. But since then, we have all these new agents. We have SWOG-S0777, which compared Rd [lenalidomide, dexamethasone] with VRd [bortezomib, lenalidomide, dexamethasone], showing that VRd [bortezomib, lenalidomide, dexamethasone] had a benefit in terms of the PFS [progression-free survival]. That became the new standard in people who were transplant ineligible.
Then the group from Boston [Massachusetts] and Wake Forest [University School of Medicine in Winston-Salem, North Carolina] started to do a spin-off of VRd [bortezomib, lenalidomide, dexamethasone] and VRd [bortezomib, lenalidomide, dexamethasone]–lite to see if that was better tolerated and had the same responses or was comparable. That’s something we’ve been adopting in our practice. Nowadays, with the anti-CD38s, we have the data of the MAIA study. That compared lenalidomide-dexamethasone vs daratumumab, lenalidomide, and dexamethasone, showing a benefit of adding daratumumab to this and a good option for transplant-ineligible [patients].
Transcript edited for clarity.
FDA Approves Cilta-Cel for Relapsed/Refractory Myeloma After 1 Therapy
April 6th 2024The FDA has approved ciltacabtagene autoleucel for the treatment of adult patients with relapsed/refractory multiple myeloma who have received at least 1 prior line of treatment, including a proteasome inhibitor and an immunomodulatory agent, and are refractory to lenalidomide.
Relapsed/Refractory Multiple Myeloma Trial Updates From ASCO 2023
August 7th 2023Experts from Mayo Clinic and The University of Texas MD Anderson Cancer Center discuss results from multiple myeloma trials presented at the 2023 American Society of Clinical Oncology Annual Meeting and how they may apply to clinical practice.