Treatment Approaches for Patients with Relapsed-Refractory MM

EP: 1.State of The Art in Multiple Myeloma: Year in Review 2022

EP: 2.Induction Regimen Options in Transplant-Eligible NDMM

EP: 3.DETERMINATION, GRIFFIN, and MASTER Studies

EP: 4.Role of Transplant and Induction Therapies in NDMM

EP: 5.Induction Therapy in Transplant-Ineligible NDMM

EP: 6.Clinical Trials in Transplant-Ineligible NDMM

EP: 7.Review of Patient Subgroups in Transplant-Ineligible NDMM

EP: 8.Final Thoughts on Transplant-Ineligible Patients with MM

Now Viewing

EP: 9.Treatment Approaches for Patients with Relapsed-Refractory MM

EP: 10.Treatment Selection of Bispecifics in Relapsed-Refractory MM

EP: 11.Rationale for Bispecific-Based Combinations in MM

EP: 12.The Role of Belantamab Mafodotin and Its Impact on Future Treatment Options

EP: 13.Management of Bispecific Toxicities and Final Thoughts on Treatments in MM

EP: 14.Evaluating Treatment Options by Patient Type in Multiple Myeloma

Transcript:

Robert Z. Orlowski, MD: Despite all the improvements in therapy for induction in both transplant-eligible and transplant-ineligible patients, unfortunately we still have patients who develop relapsed and eventually both relapsed and refractory myeloma. Fortunately, a lot of new therapies are being developed in that area that will make a huge impact. Many of them are already available, and others are soon going to be. Let’s start with Ola. We talked about using daratumumab up front, which we all agree that a patient should get if they can. Would you use daratumumab until progression and then not be able to use it second line? Or would you stop at some point and then reuse it in the second-line setting?

C. Ola Landgren, MD: That’s a good question. In my practice, I use it frequently up front. We talked about the DRd [daratumumab, lenalidomide, dexamethasone], daratumumab–VRd [bortezomib, lenalidomide, dexamethasone], and daratumumab–KRd [carfilzomib, lenalidomide, dexamethasone]. I use that a lot. Sometimes I use daratumumab–CyBorD [cyclophosphamide, bortezomib, dexamethasone]. As I mentioned, I’ve started switching from lenalidomide maintenance single drug to daratumumab with lenalidomide as 1 of my defaults. I know there isn’t a final study proving how long to do it, but I’ve started doing it about 1 year. The protocols [say to do it] 2 years or continuously.

My rationale has been that I deepen a response beyond what I do with the combination up front. If patients relapse later on, [I use] lenalidomide maintenance. I can then go back to a daratumumab-containing regimen. There’s a window that has to be taken into account. If the patient relapses a few months after you stop the combination, that’s probably not a good drug to go back to, but we all probably have the same experience. If it’s 6 or 12 or more than 12 months, you can safely go back and use it in other combinations. That’s what I frequently do.

Transcript edited for clarity.