Articles by C. Ola Landgren, MD, PhD

Use of CAR T-cell Therapy in Earlier Lines in Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how the use of CAR T-cell therapy in earlier lines of treatment for relapsed/refractory multiple myeloma could potentially improve long-term outcomes, considering factors such as patient selection, optimal timing, and the impact on subsequent treatment options.

Bispecific Selection in BCMA-failed Therapy for Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how to select appropriate bispecific antibody therapies for patients with relapsed/refractory multiple myeloma who have failed BCMA-targeted treatments, considering factors such as alternative targets, mechanisms of resistance, and emerging clinical data to provide effective subsequent treatment options.

Sequencing Therapies for Relapsed Refractory Multiple Myeloma: Bispecifics or CAR T-cell Therapy
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how to optimize the sequencing of bispecific antibodies and CAR T-cell therapies in relapsed/refractory multiple myeloma, considering factors such as patient characteristics, disease burden, and the unique advantages of each approach to maximize treatment efficacy and patient outcomes.

Patient Case: A 67-Year-Old, BCMA-Naïve, Woman with Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how to tailor treatment strategies for a 67-year-old, BCMA-naïve woman with relapsed/refractory multiple myeloma, weighing the potential benefits of BCMA-targeted therapies against other available options in the context of her specific clinical presentation.

Patient Case: A 68-Year-Old Woman with Triple Class Exposed Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how to approach treatment decisions for a 68-year-old woman with triple-class exposed relapsed/refractory multiple myeloma, considering factors such as prior therapies, disease characteristics, and emerging treatment options to optimize her care.

CARTITUDE-4: Cilta-cel vs Standard of Care Therapies in Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how the CARTITUDE-4 trial results show cilta-cel's superior efficacy over standard of care therapies in treating relapsed/refractory multiple myeloma, potentially reshaping treatment paradigms for this patient population.

KarMMa-3: Ide-cel vs Standard of Care Therapies in Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how the KarMMa-3 trial results demonstrate superior efficacy of ide-cel compared to standard of care therapies in patients with relapsed/refractory multiple myeloma, potentially establishing a new benchmark for treatment in this setting.

Ide-Cel: Real-World Outcomes for Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how ide-cel, a CAR T-cell therapy, demonstrates promising real-world outcomes in patients with relapsed/refractory multiple myeloma, potentially offering a valuable treatment option for this challenging patient population.

Treatment Strategies in Relapsed Refractory Multiple Myeloma
ByEhsan Malek, MD ,Peter Leif Bergsagel, MD,Rahul Banerjee, MD, FACP,Krina Patel, MD, MSc ,Tiffany Richards, PhD, ANP-BC, AOCNP ,Rafael Fonseca, MD,Sridevi Rajeeve, MD ,C. Ola Landgren, MD, PhD Panelists discuss how novel therapeutic approaches and combination regimens are reshaping the landscape of treatment for patients with relapsed/refractory multiple myeloma, offering new hope for improved outcomes and quality of life.

A panel of experts discuss unmet needs in multiple myeloma and offer perspectives on the future treatment landscape.

An expert panel compares bispecific antibodies with CAR T-cell therapy and discusses treatment sequencing.

Experts on multiple myeloma discuss the management of adverse effects from bispecific antibodies.

An expert panel discusses bispecific antibodies and their mechanisms of action in the treatment of relapsed/refractory multiple myeloma.

An overview of multiple myeloma treatment options in the frontline and relapsed settings.

Experts on multiple myeloma discuss approaches to laboratory workup and patient monitoring at the time of relapse.

Experts present the case of a 58-year-old patient with IgG kappa multiple myeloma and offer their initial impressions.

Clinical insights on treatment duration and the decision to place patients with newly diagnosed MM on maintenance therapy.

Insights gleaned from the MAIA trial, which researched daratumumab, lenalidomide, and dexamethasone in patients with newly diagnosed MM.

Myeloma experts present the case of a 74-year-old with transplant-ineligible newly diagnosed MM and offer their initial impressions.

An expert panel discusses maintenance therapy for patients with MM and offers insights on how induction therapy impacts treatment options.

Experts on multiple myeloma (MM) discuss factors that determine transplant eligibility for patients who are newly diagnosed.

An overview of triplet and quadruplet induction regimens used for the treatment of patients with transplant-eligible newly diagnosed multiple myeloma.

A panel of experts present a profile of a patient with newly diagnosed multiple myeloma (NDMM) and offer their initial thoughts.

C. Ola Landgren, MD, PhD, illustrated how minimal residual disease tracking may allow greater treatment personalization in the future.

C. Ola Landgren, MD, PhD, speaks about transplant eligibility, as well as new therapies and minimal residual disease negativity, in the multiple myeloma space.

C. Ola Landgren, MD, PhD, discusses the benefits obtained when patients have access to a full team of diverse caregivers rather than just a single physician.

C. Ola Landgren, MD, PhD, reviewed the plethora of emerging treatment options in multiple myeloma, and how unmet needs in the space can be overcome.

Management of Bispecific Toxicities and Final Thoughts on Treatments in MM
ByRobert Z. Orlowski, MD, PhD,Amrita Y. Krishnan, MD,C. Ola Landgren, MD, PhD,Ajay K. Nooka, MD,Cesar Rodriguez, MD Closing out the panel discussion, experts review the management of bispecific-related toxicities and share their final thoughts on treating patients with multiple myeloma.

The Role of Belantamab Mafodotin and Its Impact on Future Treatment Options
ByRobert Z. Orlowski, MD, PhD,Amrita Y. Krishnan, MD,C. Ola Landgren, MD, PhD,Ajay K. Nooka, MD,Cesar Rodriguez, MD Expert oncologists discuss Belantamab mafodotin, its recent withdrawal from the U.S. market, and the clinical implications of the DREAMM trials for patients with R/R multiple myeloma.

Rationale for Bispecific-Based Combinations in MM
ByRobert Z. Orlowski, MD, PhD,Amrita Y. Krishnan, MD,C. Ola Landgren, MD, PhD,Ajay K. Nooka, MD,Cesar Rodriguez, MD Shared perspective on the potential role of ADCs, CAR T-cell therapy, and other agents in combination treatment with bispecifics for patients with multiple myeloma.