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Opinion|Videos|November 24, 2025

Risk of Infection and IVIG Use

Author(s)C. Ola Landgren, MD, PhD, Noopur Raje, MD

Panelists discuss how infection prevention and selective IVIG use are critical for maintaining safety during NDMM combination therapy.

Episodes in this series

2 experts are featured in this series.

EP. 1 Review of Latest Guidelines on Quad Therapy in NDMM

2 experts are featured in this series.

EP. 2 Classifying High-Risk Patients With NDMM

2 experts are featured in this series.

EP. 3 Pretesting Prior to Quad Therapy for NDMM

2 experts are featured in this series.

EP. 4 Overview of the ADVANCE Study: Methodology and Design

2 experts are featured in this series.

EP. 5 Expert Perspectives on the Design of the ADVANCE Trial

2 experts are featured in this series.

EP. 6 Key Efficacy Results From ADVANCE: MRD Negativity Stratified by Age and Risk

2 experts are featured in this series.

EP. 7 Transplant Eligible vs Ineligible: Clinical Implications

2 experts are featured in this series.

EP. 8 Safety Signals of Daratumumab + KRd: Real-World Translation

2 experts are featured in this series.

EP. 9 Risk of Infection and IVIG Use

2 experts are featured in this series.

EP. 10 Final Thoughts and Future Innovations

EP. 11 Daratumumab Combo Yields Significantly Higher MRD Negativity in Multiple Myeloma

EP. 11 Daratumumab Combo Yields Significantly Higher MRD Negativity in Multiple Myeloma

Panelists discuss how infection risk remains a significant concern in newly diagnosed multiple myeloma (NDMM), particularly with immunosuppressive regimens such as daratumumab-based combinations. They share strategies for prevention and management, including vaccination, prophylaxis, and selective use of intravenous immunoglobulin (IVIG), in patients with recurrent infections or hypogammaglobulinemia. They emphasize balancing infection control with therapy intensity, noting that proactive management can sustain treatment continuity and improve outcomes.

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