Lyudmila Bazhenova, MD, Discusses the Reasoning Behind Testing for EGFR Exon 20 Insertions in NSCLC at 2021 WCLC

CancerNetwork® sat down with Lyudmila Bazhenova, MD, at the 2021 World Conference on Lung Cancer to talk about immunotherapy response in patients with EGFR exon 20 insertion mutations.

At the 2021 World Conference on Lung Cancer, CancerNetwork® spoke with Lyudmila Bazhenova, MD, of University of California at San Diego, about methods and objectives of a study that investigated response to immunotherapy in patients with EGFR exon 20 insertion mutant non–small cell lung cancer versus those with wild-type disease.


Patients with EGFR exon 20 insertion [mutations] are the third most prevalent class of EGFR mutant non–small cell lung cancer [and] those patients were excluded from the majority of the clinical trials. With immune checkpoint inhibitors, we really don’t know how those patients perform when given immunotherapy. We also don’t know how many of those patients receive immunotherapy in real life. Therefore, we used our flatiron database spanning the years of 2015 to 2020. The reason why we selected those years was because those were the years where immune checkpoint inhibitors became widely available and used in the community. This [analysis] separated the patients into the EGFR exon 20 insertion [mutant disease] cohort, and a wild-type non–small cell lung cancer cohort, which we defined [with an] EGFR-and ALK-negative test.


Bazhenova L, Girard N, Minchom A, et al. Comparative Clinical Outcomes Between EGFR Exon20ins and Wildtype NSCLC Treated with Immune Checkpoint Inhibitors. Presented at: 2021 World Conference on Lung Cancer; September 8-14, 2021. Virtual. Abstract P08.04.

Related Videos
An expert from Dana-Farber Cancer Institute discusses findings from the final overall survival analysis of the phase 3 ENGOT-OV16/NOVA trial.
The use of palliative care in ovarian cancer resulted in a decrease in overall readmissions and index hospitalization costs.
Current clinical trials look to assess 177Lu-PSMA-617 in combination with other therapies including androgen deprivation therapy and docetaxel.
An expert from Dana-Farber Cancer Institute indicates that patients with prostate cancer who have 1 risk factor should undergo salvage radiotherapy following radical prostatectomy before their prostate-specific antigen level rises above 0.25 ng/ml.
An expert from Weill Cornell Medicine highlights key clinical data indicating the benefits of radium-223 in the treatment of patients with metastatic castration-resistant prostate cancer.
The risk of radionuclide exposure to the public reflects one reason urologists need to collaborate with radiation oncologists when administering radiopharmaceuticals to patients with prostate cancer.
Switching out beta emitters for alpha emitters, including radium-223, is one way to improve radiopharmaceutical treatment of prostate cancer, according to an expert from Weill Cornell Medicine.
Data demonstrate the feasibility of automated glomerular filtration rate prediction to decide between partial nephrectomy and radical nephrectomy in kidney cancer, according to an expert from the Cleveland Clinic.
Early phase trials investigating cellular therapies, bispecific antibodies, and antibody-drug conjugates for refractory kidney cancer may uncover strategies to overcome resistance mechanisms.
Related Content