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Optimal Strategies for Managing Adverse Events with CAR-T Therapy in Multiple Myeloma : Episode 2

Navigating CAR T-Cell Therapy in Multiple Myeloma: A Collaborative, Patient-Centered Approach

June 5, 2024
By Beth Faiman, PhD, CNP
Louis Williams, MD
  • Donna Catamero, ANP-BC, OCN, CCRC
  • Tiffany Richards, PhD, ANP-BC

Opinion
Video

Experts on multiple myeloma discuss how they educate and prepare patients who are going to receive CAR T-cell therapy and provide clinical insights on transitioning patients to community practices following treatment.

EP: 1.Unique Challenges in Managing Adverse Events Associated with CAR T-Cell Therapy

Now Viewing

EP: 2.Navigating CAR T-Cell Therapy in Multiple Myeloma: A Collaborative, Patient-Centered Approach

EP: 3.Patient Profile 1: Managing CRS Following CAR T-Cell Therapy

EP: 4.Underlying Mechanisms and Signs of CRS

EP: 5.Strategies to Manage or Mitigate CRS

EP: 6.Patient Profile 2: Managing ICANS Following CAR T-Cell Therapy

EP: 7.Clinical Practices for Treating ICANS Following CAR T-Cell Therapy

EP: 8.The Importance of Multidisciplinary Collaboration in CRS Management

EP: 9.Supportive Care Strategies for CAR T-Cell Therapy Recipients

EP: 10.Managing Cytopenias and HLH/MAS Following CAR T-Cell Therapy

EP: 11.Unmet Needs and Future Perspectives for CAR T-Cell Therapy in R/R MM

Video content above is prompted by the following questions:

  • How do you prepare patients who are going to receive CAR T-cell therapy? What are you telling them?

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Recent Videos
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
4 experts are featured in this series.
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Busulfan/melphalan elicited higher PFS among patients with ISS2 or ISS3 disease, and melphalan-200 improved PFS in ISS1 disease.

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Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

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FDA Removes REMS, Lessens Requirements of Liso-cel/Ide-cel in Blood Cancers

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The FDA had reduced driving and geographic restrictions to 2 weeks for patients with lymphomas and multiple myeloma receiving liso-cel and ide-cel.


More than 70% of patients achieve an objective response with isatuximab plus pomalidomide and dexamethasone in the phase 2 EAE115 trial.

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Busulfan/melphalan elicited higher PFS among patients with ISS2 or ISS3 disease, and melphalan-200 improved PFS in ISS1 disease.

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Busulfan/melphalan elicited higher PFS among patients with ISS2 or ISS3 disease, and melphalan-200 improved PFS in ISS1 disease.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma

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Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.


Data supporting the FDA decision came from the phase 1/2 LINKER-MM1 (NCT03761108) trial.

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Data supporting the FDA decision came from the phase 1/2 LINKER-MM1 trial.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

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September 30th 2024
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James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


FDA Removes REMS, Lessens Requirements of Liso-cel/Ide-cel in Blood Cancers

FDA Removes REMS, Lessens Requirements of Liso-cel/Ide-cel in Blood Cancers

Tim Cortese
June 27th 2025
Article

The FDA had reduced driving and geographic restrictions to 2 weeks for patients with lymphomas and multiple myeloma receiving liso-cel and ide-cel.


More than 70% of patients achieve an objective response with isatuximab plus pomalidomide and dexamethasone in the phase 2 EAE115 trial.

Isatuximab Combo Shows Preliminary Activity in Pretreated Multiple Myeloma

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More than 70% of patients achieve an objective response with isatuximab plus pomalidomide and dexamethasone in the phase 2 EAE115 trial.

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