(P006) A Retrospective Cohort Analysis of Accelerated Partial Breast Irradiation (APBI) and Whole-Breast Radiation in Patients With Early-Stage Breast Cancer: Toxicities and Clinical Outcomes in a Community Cancer Center

Publication
Article
OncologyOncology Vol 30 No 4_Suppl_1
Volume 30
Issue 4_Suppl_1

The rate of recurrence was comparable between patients undergoing APBI and whole-breast radiation. Acute side effects were significantly decreased in the APBI group.

Imraan Jan, Kamila Nowak, MD, Alexandra Hanlon, PhD, Diana Dickson-Witmer, MD, Emily Penman, MD, Christopher Koprowski, MD; Helen F. Graham Cancer Center; Sidney Kimmel Medical Center; University of Pennsylvania

PURPOSE: Radiation therapy (RT) following breast-conserving surgery (BCS) for early-stage breast cancer has been shown to significantly reduce the risk of recurrence and the risk of breast cancer–specific death. Recent efforts have focused on investigating the feasibility of accelerated partial breast irradiation (APBI) following BCS in low-risk patients. The aim of this retrospective study is to compare clinical outcomes of patients undergoing APBI and whole-breast irradiation.

METHODS: A total of 344 patients with ductal carcinoma in situ or early-stage breast cancer undergoing breast conservation treatment from January 2009 to January 2014 were reviewed. All APBI patients were treated with the Strut-Assisted Volume Implant (SAVI) device. Acute toxicities, such as radiodermatitis, edema, pain, fatigue, and infection, were recorded, as well as long-term outcomes. Comparisons across treatment groups were done using Fisher’s exact and chi-square tests for categorical variables and two-sample t-tests for continuous variables.

RESULTS: Median follow-up was 24.7 months for whole-breast patients and 26.7 months for APBI patients. The Kaplan-Meier 5-year estimated recurrence-free survival was 96%. There was no difference between the two cohorts. There were three local failures in the APBI cohort. There was one local failure in the whole-breast cohort, and two patients developed distant metastases. Acute toxicities, such as fatigue, pain, and radiodermatitis, were decreased in the APBI cohort as compared with the whole-breast cohort (P < .05). Tumor stage was the only variable to demonstrate a statistically significant difference in recurrence (P = .0043) on multivariate analysis.

CONCLUSIONS: The rate of recurrence was comparable between patients undergoing APBI and whole-breast radiation. Acute side effects were significantly decreased in the APBI group.

Proceedings of the 98th Annual Meeting of the American Radium Society - americanradiumsociety.org

Articles in this issue

(S002) A 15-Year Review of Radiation Therapy for Keloids at Two Institutions
(S003) Single-Fraction Radiation Therapy for the Treatment of Multiple Myeloma Bony Metastases Provides Pain Control and Decreases Time to Chemotherapy
(S001) Prognostic Value of Pretreatment Serum Inflammatory Markers in Patients Receiving Radiation Therapy for Oropharyngeal Cancer
(S004) Trend in Second Malignancy Risk for Head and Neck Cancer With Increased Utilization of IMRT: Analysis of SEER Database
(S005) Comparison of Legal Needs of a Group of Patients With Cancer: Economic and Geographic Factors
(S006) Mission Improvement: Lessons From Initiating a Resident-Led Quality Improvement Project on Smoking Cessation at a County Hospital
(S007) Results of a Phase II Trial Using Cetuximab Plus Docetaxel With Low-Dose Fractionated Radiation for Recurrent Unresectable Locally Advanced Head and Neck Carcinoma
(S008) The Effect of Simulation and Treatment Delays for Patients With Oropharyngeal Cancer Receiving Definitive Radiation Therapy in the Era of Risk Stratification Using Smoking and Human Papilloma Virus Status
(S009) Intensity-Modulated Radiation Therapy With Stereotactic Body Radiation Therapy Boost for Unfavorable Prostate Cancer: A Report on Three-Year Toxicity
(S011) Comparative Study Between Ileal Conduit and Indiana Pouch After Cystectomy for Patients With Carcinoma of Urinary Bladder
(S010) Computed Tomography–Assessed Measures of Bone Mineral Density and Muscle Mass as Predictors of Survival in Men With Prostate Cancer
(S012) Quantitative Imaging to Evaluate the Malignant Potential of Pancreatic Cysts
(S013) Spine Stereotactic Radiosurgery With Concurrent Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma
(S014) The Impact of Radiation Therapy on Survival in Surgically Resected, High-Risk Patients With Ampullary Adenocarcinoma: A Population-Based Analysis
(S016) The Impact of Stereotactic Body Radiation Therapy on Overall Survival in Patients With Locally Advanced Pancreatic Cancer

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Recent Videos
“If you have a [patient in the] fourth or fifth line, [JNJ-5322] could be a valid drug of choice,” said Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD.
Earlier treatment with daratumumab may be better tolerated for patients with pretreated MRD-negative multiple myeloma.
The trispecific antibody JNJ-5322 demonstrated superior efficacy vs approved agents in multiple myeloma in results shared at the 2025 EHA Congress.
Despite CD19 CAR T-cell therapy exhibiting efficacy in patients with relapsed/refractory large B-cell lymphoma, less than half achieve long-term remission.
Current findings from the phase 1/2 CaDAnCe-101 trial show no predictive factors of improved responses with BGB-16673 in patients with CLL or SLL.
The phase 3 NIVOSTOP trial evaluated an anti–PD-1 immunotherapy, nivolumab, in a patient population similar in the KEYNOTE-689 trial.
Related Content