(P029) Stereotactic Radiosurgery for Intracranial Metastases of Gynecologic Origin

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Article
OncologyOncology Vol 30 No 4_Suppl_1
Volume 30
Issue 4_Suppl_1

Ablative radiotherapy with stereotactic radiosurgery or fractionated stereotactic radiotherapy was effective in treating gynecologic brain metastasis, with excellent local control.

Pericles Ioannides, BS, Strom J. Tobin, MD, Daniel C. Fernandez, MD, PhD, Michael E. Montejo, MD, Peter Johnstone, MD, Kamran A. Ahmed, MD, Michael Yu, MD; Indiana University School of Medicine; H. Lee Moffitt Cancer Center

INTRODUCTION: Gynecologic malignancy with brain metastasis is rare but has a poor prognosis. The purpose of this study was to evaluate the outcomes of patients treated with stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) to intact gynecologic brain metastases.

PATIENTS AND METHODS: From 2006–2015, a single-institution institutional review board–approved retrospective analysis identified 15 patients with 40 intracranial metastases treated with SRS (n = 33) and FSRT (n = 7). The median age was 60 years (range: 35–71 yr), with a median of 2 metastases per patient (range: 1–5). The most common primary tumor origin was ovarian (40%), followed by cervical (32.5%), endometrial (17.5%), leiomyosarcoma (5%), and choriocarcinoma (5%). The majority of intracranial treatment sites were within the frontal lobe (25%) and occipital lobe (25%). The median SRS dose was 21 Gy (range: 13–24 Gy), and the median FSRT dose was 25 Gy (range: 25–30 Gy). The median gross tumor volume was 0.37 mL (range: 0.01–17.44 mL), and the median planning target volume was 0.78 mL (range: 0.50–38.15 mL). Median follow-up was 7 months (range: 3–45 mo). Actuarial local control rate, distant brain control rate, and overall survival (OS) were assessed using Kaplan-Meier analysis.

RESULTS: The overall crude local control rate among all patients treated with SRS and FSRT was 93%, with a 12-month actuarial local control rate of 100%. Both local failures were of ovarian origin and were treated with SRS to a total dose of 20 Gy. The 12-month distant brain control and OS rates were 66.7% and 41.9%, respectively. Similarly, the median distant brain control and OS rates were 38 months (95% CI, 3–101 mo) and 40 months (95% CI, 3–82 mo), respectively.

CONCLUSION: Ablative radiotherapy with SRS or FSRT was effective in treating gynecologic brain metastasis, with excellent local control. This study provides support for the role of SRS and FSRT in the treatment of gynecologic brain metastasis.

Proceedings of the 98th Annual Meeting of the American Radium Society - americanradiumsociety.org

Articles in this issue

(S002) A 15-Year Review of Radiation Therapy for Keloids at Two Institutions
(S003) Single-Fraction Radiation Therapy for the Treatment of Multiple Myeloma Bony Metastases Provides Pain Control and Decreases Time to Chemotherapy
(S001) Prognostic Value of Pretreatment Serum Inflammatory Markers in Patients Receiving Radiation Therapy for Oropharyngeal Cancer
(S004) Trend in Second Malignancy Risk for Head and Neck Cancer With Increased Utilization of IMRT: Analysis of SEER Database
(S005) Comparison of Legal Needs of a Group of Patients With Cancer: Economic and Geographic Factors
(S006) Mission Improvement: Lessons From Initiating a Resident-Led Quality Improvement Project on Smoking Cessation at a County Hospital
(S007) Results of a Phase II Trial Using Cetuximab Plus Docetaxel With Low-Dose Fractionated Radiation for Recurrent Unresectable Locally Advanced Head and Neck Carcinoma
(S008) The Effect of Simulation and Treatment Delays for Patients With Oropharyngeal Cancer Receiving Definitive Radiation Therapy in the Era of Risk Stratification Using Smoking and Human Papilloma Virus Status
(S009) Intensity-Modulated Radiation Therapy With Stereotactic Body Radiation Therapy Boost for Unfavorable Prostate Cancer: A Report on Three-Year Toxicity
(S011) Comparative Study Between Ileal Conduit and Indiana Pouch After Cystectomy for Patients With Carcinoma of Urinary Bladder
(S010) Computed Tomography–Assessed Measures of Bone Mineral Density and Muscle Mass as Predictors of Survival in Men With Prostate Cancer
(S012) Quantitative Imaging to Evaluate the Malignant Potential of Pancreatic Cysts
(S013) Spine Stereotactic Radiosurgery With Concurrent Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma
(S014) The Impact of Radiation Therapy on Survival in Surgically Resected, High-Risk Patients With Ampullary Adenocarcinoma: A Population-Based Analysis
(S016) The Impact of Stereotactic Body Radiation Therapy on Overall Survival in Patients With Locally Advanced Pancreatic Cancer
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