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(P044) Comparison of Toxicity-Related Breaks in Treatment Utilizing Intensity-Modulated Radiation Therapy (IMRT) vs Three-Dimensional (3D) Conformal Techniques in the Treatment of Anal Cancer

April 15, 2016
Publication
Article
OncologyOncology Vol 30 No 4_Suppl_1
Volume 30
Issue 4_Suppl_1
Conference|Annual Meeting of the American Radium Society (ARS)

In our small cohorts, no significant difference was seen in toxicity-related treatment breaks between IMRT and three-dimensional conformal RT.

Eric Kemmerer, MD, Abhishek Mishra, Shreyas Ranganna,  Roderick Price, Lydia Komarnicky, MD, Jaganmohan Poli, MD; Drexel University

PURPOSE: The definitive treatment of patients with anal cancer using radiation therapy (RT) and concurrent 5-fluoropyrimidine (5-FU) and mitomycin-C (MMC) is associated with acute toxicities during treatment, which may necessitate a break in RT. Radiation Therapy Oncology Group trial 0529 reported a significant decrease in grade ≥ 3 dermatologic and gastrointestinal acute toxicities with the use of dose-painted intensity-modulated RT (IMRT) vs three-dimensional conformal RT (3DCRT) techniques. Here, we investigate whether IMRT use may result in fewer toxicity-related treatment breaks in a cohort of patients treated at our institution.

MATERIALS AND METHODS: From 2005–2015, a total of 22 patients with T1–4N0–3M0 squamous cell carcinoma of the anal canal treated with IMRT (n = 12) or 3DCRT (n = 10) were identified. Median total dose to the primary tumor overall was 50.4 Gy, with a median dose of 45 Gy (range: 45–55.8 Gy) in the 3DCRT cohort and 50.4 Gy (range: 46.8–54 Gy) in the IMRT cohort. Median age was 51 years. Further, 79% of patients received 5-FU and MMC, two patients (9%) received 3DCRT with 5-FU only, and one patient (4.5%) received 3DCRT without chemotherapy. Patients who had a documented treatment break for grade ≥ 3 acute toxicity were identified, as was the corresponding elapsed day of treatment on which the first break occurred. Time to first treatment break was examined using Kaplan-Meier analysis and log-rank testing.

RESULTS: Overall, cumulatively, 16 patients (73%) required a treatment break, at a median of 18 days of elapsed treatment. Also, 92% and 50% of IMRT and 3DCRT patients required treatment breaks, respectively (log-rank test P = .141).

CONCLUSION: In our small cohorts, no significant difference was seen in toxicity-related treatment breaks between IMRT and 3DCRT.  

Proceedings of the 98th Annual Meeting of the American Radium Society -americanradiumsociety.org

Articles in this issue

(S002) A 15-Year Review of Radiation Therapy for Keloids at Two Institutions
(S003) Single-Fraction Radiation Therapy for the Treatment of Multiple Myeloma Bony Metastases Provides Pain Control and Decreases Time to Chemotherapy
(S001) Prognostic Value of Pretreatment Serum Inflammatory Markers in Patients Receiving Radiation Therapy for Oropharyngeal Cancer
(S004) Trend in Second Malignancy Risk for Head and Neck Cancer With Increased Utilization of IMRT: Analysis of SEER Database
(S005) Comparison of Legal Needs of a Group of Patients With Cancer: Economic and Geographic Factors
(S006) Mission Improvement: Lessons From Initiating a Resident-Led Quality Improvement Project on Smoking Cessation at a County Hospital
(S007) Results of a Phase II Trial Using Cetuximab Plus Docetaxel With Low-Dose Fractionated Radiation for Recurrent Unresectable Locally Advanced Head and Neck Carcinoma
(S008) The Effect of Simulation and Treatment Delays for Patients With Oropharyngeal Cancer Receiving Definitive Radiation Therapy in the Era of Risk Stratification Using Smoking and Human Papilloma Virus Status
(S009) Intensity-Modulated Radiation Therapy With Stereotactic Body Radiation Therapy Boost for Unfavorable Prostate Cancer: A Report on Three-Year Toxicity
(S011) Comparative Study Between Ileal Conduit and Indiana Pouch After Cystectomy for Patients With Carcinoma of Urinary Bladder
(S010) Computed Tomography–Assessed Measures of Bone Mineral Density and Muscle Mass as Predictors of Survival in Men With Prostate Cancer
(S012) Quantitative Imaging to Evaluate the Malignant Potential of Pancreatic Cysts
(S013) Spine Stereotactic Radiosurgery With Concurrent Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma
(S014) The Impact of Radiation Therapy on Survival in Surgically Resected, High-Risk Patients With Ampullary Adenocarcinoma: A Population-Based Analysis
(S016) The Impact of Stereotactic Body Radiation Therapy on Overall Survival in Patients With Locally Advanced Pancreatic Cancer

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