(P103) A New Score Predicts Survival in Patients With Non–Small-Cell Lung Cancer

Publication
Article
OncologyOncology Vol 29 No 4_Suppl_1
Volume 29
Issue 4_Suppl_1

Prognostic factors that were significantly associated with survival on both UV and MV analyses were used to construct a valid scoring system that can be used to predict survival of NSCLC patients. The score can be used for trial stratification or for choosing patients specifically for high-risk trials. Optimally, this score will be helpful when counseling patients and designing future trials.

Steven E. Schild, MD, Angelina D. Tan, BS, BA, Jason A. Wampfler, BS, Julian R. Molina, MD, PhD, Helen J. Ross, MD, Ping Yang, MD, PhD, Jeff A. Sloan, PhD; Mayo Clinic

PURPOSE: This analysis was performed to create a scoring system to estimate the survival of patients with non–small-cell lung cancer (NSCLC).

METHODS: Data from 1,274 NSCLC patients were analyzed to create and validate a scoring system. Univariate (UV) and multivariate (MV) Cox models were used to evaluate the prognostic importance of each baseline factor. Prognostic factors that were significant on both univariate and multivariate analyses were used to develop the score. They included quality of life, age, performance status, primary tumor diameter, nodal status, distant metastases, and smoking cessation. The score for each factor was determined by dividing the 5-year survival rate (%) by 10 and summing these scores to form a total score. Multivariate models and the score were validated using bootstrapping with 1,000 iterations from the original samples.

RESULTS: The score for each factor ranged from 1–7 points, with higher scores reflective of better survival. Total scores of 32–37 correlated with a 5-year survival of 8.3% (95% confidence interval [CI], 0%–17.1%), 38–43 correlated with a 5-year survival of 20% (95% CI, 13%–27%), 44–47 correlated with a 5-year survival of 48.3% (95% CI, 41.5%–55.2%), 48–49 correlated to a 5-year survival of 72.1% (95% CI, 65.6%–78.6%), and 50–52 correlated to a 5-year survival of 84.7% (95% CI, 79.6%–89.8%). The bootstrap method confirmed the reliability of the score.

CONCLUSIONS: Prognostic factors that were significantly associated with survival on both UV and MV analyses were used to construct a valid scoring system that can be used to predict survival of NSCLC patients. The score can be used for trial stratification or for choosing patients specifically for high-risk trials. Optimally, this score will be helpful when counseling patients and designing future trials.

Proceedings of the 97th Annual Meeting of the American Radium Society - americanradiumsociety.org

Articles in this issue

(P005) Ultrasensitive PSA Identifies Patients With Organ-Confined Prostate Cancer Requiring Postop Radiotherapy
(P001) Disparities in the Local Management of Breast Cancer in the United States According to Health Insurance Status
(P002) Predictors of CNS Disease in Metastatic Melanoma: Desmoplastic Subtype Associated With Higher Risk
(P003) Identification of Somatic Mutations Using Fine Needle Aspiration: Correlation With Clinical Outcomes in Patients With Locally Advanced Pancreatic Cancer
(P004) A Retrospective Study to Assess Disparities in the Utilization of Intensity-Modulated Radiotherapy (IMRT) and Proton Therapy (PT) in the Treatment of Prostate Cancer (PCa)
(S001) Tumor Control and Toxicity Outcomes for Head and Neck Cancer Patients Re-Treated With Intensity-Modulated Radiation Therapy (IMRT)-A Fifteen-Year Experience
(S003) Weekly IGRT Volumetric Response Analysis as a Predictive Tool for Locoregional Control in Head and Neck Cancer Radiotherapy 
(S004) Combination of Radiotherapy and Cetuximab for Aggressive, High-Risk Cutaneous Squamous Cell Cancer of the Head and Neck: A Propensity Score Analysis
(S005) Radiotherapy for Carcinoma of the Hypopharynx Over Five Decades: Experience at a Single Institution
(S002) Prognostic Value of Intraradiation Treatment FDG-PET Parameters in Locally Advanced Oropharyngeal Cancer
(P006) The Role of Sequential Imaging in Cervical Cancer Management
(P008) Pretreatment FDG Uptake of Nontarget Lung Tissue Correlates With Symptomatic Pneumonitis Following Stereotactic Ablative Radiotherapy (SABR)
(P009) Monte Carlo Dosimetry Evaluation of Lung Stereotactic Body Radiosurgery
(P010) Stereotactic Body Radiotherapy for Treatment of Adrenal Gland Metastasis: Toxicity, Outcomes, and Patterns of Failure
(P011) Stereotactic Radiosurgery and BRAF Inhibitor Therapy for Melanoma Brain Metastases Is Associated With Increased Risk for Radiation Necrosis
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