Sandra Cuellar, PharmD, BCOP, FASHP, on Cardiotoxicity With Margetuximab for HER2+ Metastatic Breast Cancer

Video

An oncology pharmacist speaks about the occurance of left ventricular dysfunction noted with margetuximab in the treatment of HER2-positive metastatic breast cancer.

For the latest installment of the “Product Profile”, ONCOLOGY® spoke with Sandra Cuellar, PharmD, BCOP, FASHP, about margetuximab (Margenza) as therapy for patients with HER2-positive metastatic breast cancer. Here, she discusses cardiotoxicity that is frequently experienced by patients receiving monoclonal antibodies that target the HER2 receptor.

Transcript:

[Speaking specifically about] left ventricular dysfunction, just knowing the mechanism of action [of this agent and] that it targets the HER2 receptor, we know that there will be, just from the mechanistic perspective, some level of cardiotoxicity, given our [experience with] previous agents. Again, margetuximab had about 3% of cardiotoxicity, primarily manifesting as decrease in ejection fraction, [which was] asymptomatic and reversible. The management is [similar to what] we do with trastuzumab. If it’s greater than or equal to a 16% drop from pretreatment ejection fractions, you’re going to hold [the drug] and at that point, you should consult a cardiooncologist. Once it recovers, you can restart.

References

1. Rugo HS, Im SA, Cardoso F, et al. Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2021;7(4):573-584. doi:10.1001/jamaoncol.2020.7932

2. Margetuximab. Prescribing information. Macrogenics; 2020. Accessed August 23, 2021. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761150s000lbl.pdf

Recent Videos
Carey Anders, MD, an expert on breast cancer
Carey Anders, MD, an expert on breast cancer
Carey Anders, MD, an expert on breast cancer
Carey K. Anders, MD, an expert on breast cancer
A panel of 4 experts on breast cancer seated at a long table
A panel of 4 experts on breast cancer seated at a long table
A panel of 4 experts on breast cancer seated at a long table
A panel of 4 experts on breast cancer seated at a long table
Rani Bansal, MD, an expert on breast cancer
A panel of 4 experts on breast cancer seated at a long table
Related Content