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Opinion|Videos|February 17, 2025

Approach to HER2+ Metastatic Disease Treatment

Author(s)Rohit Gosain, MD, Rahul Gosain, MD, Sarah Sammons, MD

Panelists discuss how; the treatment of HER2-positive metastatic breast cancer typically involves HER2-targeted therapies combined with chemotherapy. First-line treatment usually consists of trastuzumab plus pertuzumab with a taxane. Subsequent lines may include T-DM1, tucatinib-based combinations, or other HER2-directed therapies, with treatment selection guided by disease characteristics and prior therapy response.

Episodes in this series

EP. 1 Early-Stage HER2+ Breast Cancer Treatment

EP. 1 Early-Stage HER2+ Breast Cancer Treatment

EP. 2 Locally Advanced HER2+ Breast Cancer

EP. 2 Locally Advanced HER2+ Breast Cancer

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EP. 3 Escalating to TDM-1 Treatment Therapy

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EP. 4 Approach to HER2+ Metastatic Disease Treatment

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EP. 5 Navigating Data Free HER2+ Breast Cancer Treatment

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