Bruce D. Cheson, MD | Authors

JEFFERSON PHARMACY

908 WALNUT ST

Articles

FDG-PET for Early Response Assessment in Lymphomas: Part 1-Hodgkin Lymphoma

January 15, 2017

Here we critically analyze the role of PET/CT in the early assessment of Hodgkin lymphoma.

FDG-PET for Early Response Assessment in Lymphomas: Part 2-Diffuse Large B-Cell Lymphoma, Use of Quantitative PET Evaluation

January 15, 2017

Here we review the role of interim PET/CT in diffuse large B-cell lymphoma (DLBCL), and also explore the question of whether new approaches to quantitative assessment improve the prognostic value of interim PET scans in both Hodgkin lymphoma and DLBCL.

Small Molecules, Big Challenges

April 15, 2015

With each passing year, chemotherapy is less and less a focus of interest. Instead, the focus is on the abundance of exciting new biologic and targeted agents that are bulldozing the therapeutic landscape in the lymphomas and chronic lymphocytic leukemia.

Genetic Abnormalities in CLL: Prognostic Factors-or Their Own Disease?

July 11, 2011

To find a new cure for a disease, or at least to significantly prolong patient survival, requires a bit of insight and a lot of luck.

Management of Follicular Lymphoma in the Up-Front and Relapsed Settings

December 15, 2010

A number of recent treatment advances in the management of follicular lymphoma (FL), including the introduction of the anti-CD20 monoclonal antibody rituximab, have effectively shifted the primary therapeutic goal away from palliation and avoidance of toxicity toward the more proactive objective of extending survival. This paper reviews recent practice patterns in the broad context of the published findings from major phase III randomized trials; it documents potential gaps between trial results and actual practice, and the implications of these for continuing education of oncologists. Forty-three US-based community oncologists participated in a cross-sectional case survey during which 40 documented their management of 186 patients with newly diagnosed FL and 133 patients with relapsed FL, all of whom were treated after January 1, 2008. The findings from this initiative indicate that the majority of these patients did not have any major symptoms at presentation. Additionally, tolerance of and response to treatment, regardless of the regimen employed, were similar across the different age groups studied (

Monoclonal Antibodies in Advanced B-cell Lymphomas

February 15, 2010

he treatment of B-cell malignancies has been revolutionized by the availability of safe and effective monoclonal antibodies. The addition of rituximab to standard chemotherapy regimens prolongs the survival of patients with diffuse large B-cell lymphoma (DLBCL) and follicular non-Hodgkin lymphoma. Nevertheless, indolent and mantle cell lymphomas remain incurable, and 30% to 40% of patients with DLBCL still die from their disease. Much ongoing research has focused on optimizing monoclonal antibody use, integrating them into multiagent regimens, and developing newer antibodies. Attempts to improve on the efficacy of monoclonal antibody–based therapy have included altering the dosing schedule, optimizing patient selection, maintenance therapy, improving upon the rituximab molecule, radioimmunotherapy, as well as combinations with cytotoxic molecules and other novel agents. Preliminary data with a number of treatment regimens are promising in indolent and aggressive lymphomas. The eventual goal of targeted therapies is to individualize treatment to increase response and survival, while reducing treatment-related toxicity.

Mantle Cell Lymphoma: Clinicopathologic Features and Treatments

June 01, 2003

Mantle cell lymphoma (MCL) accounts for approximately 6% of non-Hodgkin’s lymphomas. Patients usually present with advanced disease, with a tendency for extranodal involvement. MCL is an aggressive lymphoma with moderate chemosensitivity, but it remains one of the most difficult therapeutic challenges. Complete response rates to chemotherapy range from 20% to 40%, with median survivals of 2½ to 3 years. Anthracycline-containing regimens do not prolong survival compared with nonanthracycline regimens. Single-agent rituximab (Rituxan) has produced response rates of about 30%, and when combined with an anthracycline-containing regimen, response rates increase to above 90%; however, an impact on survival has not yet been demonstrated. More intensive regimens such as hyperCVAD (hyperfractionated cyclophosphamide [Cytoxan, Neosar], vincristine, doxorubicin [Adriamycin], dexamethasone, methotrexate, cytarabine) with either stem cell transplant or rituximab have been associated with promising results.

Monoclonal Antibodies in Hematologic Malignancies: Targeted Approaches to Treatment

March 01, 2003

Anyone who attended the2002 American Society ofHematology (ASH) meetingin Philadelphia couldnot help but be impressedby the number of reportsof clinical trials of biologicagents. In particular,monoclonal antibody–based strategies were describedin a broad range of malignant andbenign conditions. As the reports of singleagentactivity of drugs such as rituximab (Rituxan)diminished for lymphoma trials, thenumber of chemotherapy regimens to which theantibody has been added blossomed. Whensingle-agent data were presented, they oftenrepresented longer-term follow-up with additionalpatients, confirming the safety and efficacyof these agents. Some studies describedattempts at improving the activity of antibodies,whereas others have been evaluating their rolein new malignant and benign indications.

Current Clinical Trials in Non-Hodgkin’s Lymphoma

June 01, 2002

The non-Hodgkin’s lymphomas (NHL) are the fifth most common cause of cancer in men and women in the United States, and the fifth and sixth leading causes of cancer deaths, respectively. Approximately 54,000 new cases are projected to be diagnosed in the United States this year,[1] 25% to 30% of which are indolent histologies, with the remainder being aggressive tumors.