Strategies for Identification and Clinical Evaluation of Promising Chemopreventive Agents
ByGary J. Kelloff, MD,Ernest T. Hawk, MD, MPH,Charles W. Boone, MD, PhD,Susan G. Nayfield, MD, MSC,Marjorie Perloff, MD,Vernon E. Steele, PhD, MPH,Ronald A. Lubet, PhD,Caroline C. Sigman, PhD
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Strategies for chemopreventative drug development are based on the use of well-characterized agents, intermediate biomarkers correlating to cancer incidence, and suitable cohorts for efficacy studies. Since