Revised Prescribing Information for Oxaliplatin Includes 6-Year Survival DataJuly 1st 2008
Sanofi-aventis US announced that the US Food and Drug Administration (FDA) approved the supplemental new drug application (sNDA) to include 6-year overall survival analysis from the MOSAIC trial in the oxaliplatin (Eloxatin) prescribing information (PI). The new PI also reports 5-year disease-free survival (DFS) data in stage III colon cancer patients treated following surgery to remove the primary tumor.
Breast Cancer Risk Amplified by Additional Genes in Combination With Damaged BRCA GenesMay 2nd 2008
Many women with a faulty breast cancer gene could be at greater risk of the disease due to extra risk-amplifying genes, according to research published recently in the American Journal of Human Genetics.
Novel Capecitabine Dosing May Offer Well-Tolerated Alternative for Treating Advanced Breast CancerMay 2nd 2008
A novel biweekly dosing schedule of capecitabine (Xeloda) enabled safe delivery of higher daily doses in the treatment of advanced breast cancer, according to an investigational study published in the Journal of Clinical Oncology.
Professionalism and Cancer CareMay 2nd 2008
It is particularly appropriate that this issue published in tribute to the late Martin Abeloff include an article on professionalism in oncology. This is partly because there was no better example of professional behavior than Marty. Also, many might not realize that he published his thoughts on this topic 14 years ago.
Martin Abeloff and the Quality-of-Life MovementMay 2nd 2008
Integrative oncology, the synthesis of gold-standard care and evidence-based complementary modalities, deals not only with the patient’s tumor, but also with her physical and emotional needs and with the relevant cultural, scientific, and policy issues. This synthesis was one of Marty Abeloff’s main professional goals.
Tracking 35 Years of Progress Against Breast CancerMay 2nd 2008
In this issue of ONCOLOGY we honor and celebrate the career and contributions of Martin D. Abeloff, MD, who died last year. Marty saw his first patient with breast cancer in 1972 and cared for his last such patient shortly before his death in 2007.
Psychological and Social Aspects of Breast CancerMay 1st 2008
Breast cancer treatments today are likely to cause less physical deformity from surgery than a half-century ago, but are more complex and extend over a longer period of time. Women today are often well informed about the details of their cancer diagnosis and prognosis, and are increasingly involved in shared decision-making regarding treatment.
The Importance of Communication in Treating Women With Breast CancerMay 1st 2008
In her article on the psychological and social aspects of breast cancer, Dr. Ganz pays fitting tribute to the pioneering and prescient efforts of a great man who tried hard to bring more humanity into the management of the disease.
Adjuvant Therapy for Breast Cancer: Current Approaches and Strategies for a Better FutureMay 1st 2008
Worldwide, breast cancer is by far the most frequent cancer affecting women, with over 1 million new cases each year, and the leading cause of female cancer-related deaths. During the past decade, substantial progress has been made in the treatment of breast cancer, due to focused collaborative efforts in education, practice, and research.
Therapeutic Options in the Management of Metastatic Breast CancerMay 1st 2008
Novel agents are adding to the wide choices of standard chemotherapies already available. This review offers an approach to the selection of individualized and rational therapies for patients with metastatic breast cancer.
Metastatic Breast Cancer: How Far We’ve ComeMay 1st 2008
In order to frame this commentary on Higgins and Wolff’s review of current treatment options for metastatic breast cancer, I started with a PubMed search of Dr. Marty Abeloff’s work from more than 3 decades ago. This was partly motivated by my own curiosity about a leader whose early career was largely unknown to me, and partly by the desire to see whether “the more things change, the more they remain the same.”
Where a Woman Lives May Affect Her Breast Cancer TreatmentMay 1st 2008
Women in the Northeast US are more likely to receive breast-conservation therapy, while those in the South are more often recommended for mastectomies for the treatment of invasive breast cancer, according to a study presented at the 9th Annual Meeting of the American Society of Breast Surgeons (ASBS), held April 30 to May 4 in New York.
Mammography May Be Beneficial to All Women, Regardless of AgeMay 1st 2008
According to researchers at The University of Texas M. D. Anderson Cancer Center, mammography, the gold-standard for breast cancer screening and early detection, has shown to significantly reduce the risk of being diagnosed with advanced-stage breast cancer in women over 80 years old, an age group currently without clear guidelines for regular screenings.
The New Millennium for Adjuvant Therapy in Breast CancerMay 1st 2008
The treatment of microscopic metastatic breast cancer with adjuvant systemic therapy has undergone significant changes in recent years. At the same time, our understanding of the biology of breast cancer has also improved, predominantly as a consequence of data obtained from cDNA microarrays.
Preventing Breast Cancer in High-Risk Women, 2008May 1st 2008
Several large, prospective trials have evaluated tamoxifen compared with placebo for breast cancer risk reduction in women at increased risk for breast cancer. Analysis of the large, prospective breast cancer risk-reduction trials that used tamoxifen estimated that tamoxifen decreased breast cancer incidence by 38% on average and estrogen receptor–positive tumors by 48%.
Victor Vogel’s excellent review of the clinical basis for preventing breast cancer in high-risk women demonstrates the significant advances that have been made through the clinical trials mechanism. However, it is the progress in deciphering the link between hormones and the development and growth of breast cancer that is the true success story in this setting.