Oncology Vol 28 No 7

Updates on the Management of Breast Cancer Brain Metastases

July 15, 2014

In this overview, we will review recent developments in the management of breast cancer brain metastases and current prospective trials of systemic therapies specifically for patients with breast cancer brain metastases, with a focus on novel pathway-specific therapies.

‘Watch-and-Wait’ for Rectal Cancer: What's the Way Forward?

July 15, 2014

Rectal cancer management is becoming increasingly complex. There is increasing recognition of the potential to avoid routine chemoradiotherapy, as excellent results can be achieved with a more selective approach.

Role of Surgical Resection in Primary CNS Lymphoma: A Resurrected Discussion

July 15, 2014

For the practicing medical or neuro-oncologist, the treatment approach would currently not change, given that systemic therapy should be started as soon as the diagnosis of PCNSL is made and the patient is stable from a neurosurgical perspective. In most cases, one would not refer the patient back to the surgeon for additional debulking.

Surgery for Primary Central Nervous System Lymphoma: Is It Time for Reevaluation?

July 16, 2014

Relatively few patients with primary diffuse large B-cell lymphoma (PCNSL) will have tumors that are amenable to resection. In the absence of the highest quality data, at least it is good to know that in the modern era, patients with PCNSL are probably not harmed by judicious tumor resection.

Nonoperative Strategies for Rectal Cancer Following a Complete Clinical Response to Preoperative Chemoradiation: A Few Considerations

July 15, 2014

Although the current standard treatment for patients with locally advanced rectal cancer is preoperative chemoradiotherapy followed by total mesorectal excision, concerns have been raised over the functional sequelae and possible overtreatment of rectal cancer patients.