Detecting Disease Early Via AI in Black Pancreatic Cancer Populations
AI may open pathways to locate pancreatic cancer earlier and in higher-risk patient subgroups, according to Debiao Li, PhD, and Stephen Pandol, MD.
NFKB1 Haplotype Boosts Response to Ropeginterferon in MPN Subtypes
NFKB1 rs230511 genetic variant improves treatment outcomes for patients with polycythemia vera and essential thrombocythemia.
PFS Boost Occurs With Tafasitamab Combo in R/R Follicular Lymphoma
Phase 3 data support tafasitamab plus lenalidomide/rituximab as a potential new standard of care in patients with relapsed/refractory follicular lymphoma.
Advancing Pancreatic Cyst Surveillance and Care Pathways Via AI Software
An artificial intelligence model may help move patients into treatment pathways for pancreatic cancer quicker, says Russell C. Langan, MD, FACS, FSSO.
No Clinical Benefit Added Using Auto-HCT/Rituximab in MCL Cohort
Autologous transplant did not confer significantly improved overall survival regardless of induction intensity in a phase 3 trial.
Positive PFS and EFS Outcomes Were Elicited by Pirtobrutinib in CLL and SLL
Pirtobrutinib sustained BTK inhibition and improved progression-free survival in patients with CLL and SLL, data from the phase 3 BRUIN CLL-321 trial showed.
Asciminib Appears to Benefit All Chronic Myeloid Leukemia Subgroups
Compared with second-generation tyrosine kinase inhibitors, asciminib was better tolerated in patients with chronic myeloid leukemia.
Axi-cel Demonstrated Strong Durable Response and Survival in RR NHL
Long-term ORR, DOR, PFS, and OS data from the phase 2 Zuma-5 trial supports the use of axi-cel use in relapsed/refractory indolent Non-Hodgkin lymphoma treatment.
ORR, DOR, and Safety Outcomes with Lisaftoclax Combo Were Strong in RRMM
Lisaftoclax with pomalidomide and dexamethasone elicited positive efficacy and safety outcomes in relapsed/refractory multiple myeloma.
Brexu-cel Yielded High ORRs and Durability in R/R Mantle Cell Lymphoma
Regardless of high-risk features, brexucabtagene autoleucel demonstrated positive and durable responses in BTK-naive MCL.
Pirtobrutinib Triplet Improves MRD Outcomes in CLL
Phase 2 results showed high undetectable MRD rates with pirtobrutinib, venetoclax, and obinutuzumab for patients with chronic lymphocytic leukemia.
Positive ORRs Yielded by Glofitamab Regimen in R/R Large B-Cell Lymphoma
Glofitamab with polatuzumab vedotin benefited patients with high-grade B-cell lymphomas and who failed prior CAR T-cell therapy.
Subcutaneous Epcoritamab Shows Durable Responses in Elderly B-Cell Lymphoma
Phase 2 data support epcoritamab monotherapy as a promising chemotherapy-free option for older patients with newly diagnosed LBCL.
BTK Degrader BGB-16673 Shows Promise in R/R WM and CLL/SLL
Findings from the phase 1/2 CaDAnCe-101 trial showed that promising ORRs in R/R WM and R/R CLL/SLL stemmed from BGB-16673 treatment.
Overall MRD Negativity Rates Improved with Cilta-cel vs SOC in MM
In patients with lens-refractory multiple myeloma, cilta-cel generated deeper minimal residual disease rates across all patient subgroups.
Reduction in AEs by Pelabresib With Ruxolitinib in JAK-Naive Myelofibrosis
Pelabresib and ruxolitinib combination maintains consistent reduction of symptoms and anemia in patients with myelofibrosis.
Sonrotoclax/Zanubrutinib Combo Elicits Deep Responses for Untreated CLL/SLL
For patients with CLL and SLL, sonrotoclax with zanubrutinib yielded high rates of overall response in the phase 1/1b BGB-11417-101 study.
ESAs Yields Response in VEXAS Syndrome With or Without MDS
In patients with VEXAS Syndrome with or without MDS, ESAs/luspatercept generated positive hematologic improvement-erythroid responses.
Individually Optimizing Cancer Outcomes Through a Mission of Survivorship Care
A panel of cancer survivorship experts outline major areas of focus and care models for improving outcomes among pediatric and adult survivors of cancer.
Superior Rates of MRD Upheld by Isatuximab Combo in Multiple Myeloma
Patients with newly diagnosed multiple myeloma experienced sustained MRD negativity with isatuximab/bortezomib/lenalidomide/dexamethasone.
Belantamab Mafodotin Regimen Improves OS in R/R Multiple Myeloma
Findings from DREAMM-7 support belantamab mafodotin plus bortezomib and dexamethasone as a standard of care in relapsed/refractory multiple myeloma.
General Lifestyle Recommendations for Receiving Talquetamab in Multiple Myeloma
Samatha Shenoy, NP, MSN, highlighted lifestyle recommendations to help patients who are receiving talquetamab treatment for multiple myeloma.
Pafolacianine Shows No Serious Adverse Effects in Lung Cancer Surgery
The 2 main pafolacianine components, a folate analog and a dye, are commonly used in other medical applications.
Cardiac AEs Decrease With 2nd-Generation BTK Inhibitors in B-Cell Cancers
Atrial fibrillation occur at a smaller likelihood with second-generation BTK inhibitors vs first-generation BTK inhibitors in B-cell hematologic cancers.
Uproleselan Does Not Reach OS End Point, Shows Select Efficacy in AML
Phase 3 data show meaningful benefits with uproleselan in patients with primary refractory AML and post-transplant survival.
Zanubrutinib Remains Frontline Option During 5-Year Follow-Up for CLL/SLL
Zanubrutinib maintained a PFS benefit at 5 years vs benadmustine and rituximab for patients with CLL/SLL.
Data Show Long-Term Activity With Tisagenlecleucel in Follicular Lymphoma
Tisagenlecleucel shows high rates of MRD-negative status among patients with relapsed/refractory follicular lymphoma in the ELARA trial.
Venetoclax/Cladribine Improves Response Rates in AML/MDS Cohorts
The venetoclax regimen improved CR/CRi rates for patients with acute myeloid leukemia and myelodysplastic syndromes.
Non-Relapse Mortality Rates in B-ALL and MCL Consistent With Lymphodepletion/Brexu-Cel Treatment
For patients with acute lymphoblastic leukemia and mantle cell leukemia, lymphodepletion then brexu-cel show positive efficacy and safety outcomes.
Venetoclax Plus Hypomethylating Agents Elicit Encouraging Responses in MDS
Minimal tumor lysis syndrome was observed with venetoclax combined with hypomethylating agents in patients with myelodysplastic syndrome.