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OAK BROOK, Ill--Young physicians seeking careers in radiation on-cology may have severely limited employment opportunities in the foreseeable future, according to the American College of Radiation Oncology (ACRO). The College forecasts that up to 1,000 radiation oncologists will be either underemployed or unemployed shortly after the year 2000.

WASHINGTON--The new director of the National Cancer Institute envisions the NCI as an institute focused on science, but with a responsibility toward the community to disseminate information and be involved in larger issues.

In Los Angeles, the future seems to arrive a little sooner than in the rest of the country. The defense-based economy has crashed and burned, shifting hundreds of thousands of employees into managed care plans, mostly HMOs.

PHILADELPHIA--The clinical practice guidelines developed by the National Comprehensive Cancer Network (NCCN), to be presented at the coalition's first conference in March, represent the first step toward a larger goal--developing a database of how those guidelines are used throughout the network.

BETHESDA, Md--At its most recent meeting, the National Cancer Advisory Board heard a report on the Division of Cancer Treatment, Diagnosis, and Centers and its efforts to promote third-party payer support for clinical trials.

BETHESDA, Md--The American Urologic Association has named Judd W. Moul, MD, Prostate Educator of the Year. Dr. Moul is director, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences.

WASHINGTON--The original 'war on cancer' was declared by the President of the United States in 1971, and a cure was promised within 10 years. In that same year, Texas Instruments was developing the first pocket calculator and Intel had just introduced the microchip, said financier Michael R. Milken at the National Cancer Summit. The meeting was sponsored by the Association for the Cure of Cancer of the Prostate (CaP CURE, see box on page 20), which Mr. Milken founded, and by other leading cancer organizations.

Acquired susceptibility mutation--A mutation in a gene that occurs after birth from a carcinogenic insult. Allele--One of several mutational forms of a specific gene.

WASHINGTON--The George Washington University Medical Center will soon be providing mobile mammog-raphy services in Washington, DC. Allan B. Weingold, MD, vice president for medical affairs, announced the project at the Fifth Annual Jo Oberstar Memorial Lecture, delivered by Tipper Gore, wife of Vice President Al Gore (see box below).

WASHINGTON--In 1990, General H. Norman Schwarzkopf commanded the imagination of the American people during his service as Commander of Operations Desert Shield and Desert Storm. At the First National Congress on Cancer Survivorship, he stormed the stage of the Washington Court Hotel to describe his role as a prostate cancer survivor and patient advocate. The message was simple and personal. "I am here," the general said, "because I won a battle."

NUTLEY, NJ--Vesanoid (treti-noin, all-trans-retinoic acid) has become the first retinoid to receive a cancer treatment indication from the US Food and Drug Administration. The new agent, from Hoffmann-La Roche, is indicated for induction of remission in patients with acute promyelocytic leukemia (APL) who are refractory to or have relapsed from anthracycline chemotherapy, or for whom anthracy-cline chemotherapy is contraindicated.

A malfunctioning "traffic cop" gene apparently plays an important role in the formation of liver cancer, according to researchers from the Duke University Comprehensive Cancer Center and Zeneca Pharmaceuticals of Chesire, United Kingdom.

SEATTLE--DNA from the recently discovered Kaposi's sarcoma-associated herpesvirus (KSHV) has been isolated in KS lesions as well as some AIDS-related lymphomas, and the new research suggests that foscarnet (Foscavir) may effectively inhibit the virus. Enrique. A. Mesri, PhD, of the Department of Medicine, Cornell University Medical College, reported the findings at the American Society of Hematology (ASH) meeting.

Corticosteroids have not been approved by the FDA for use as antiemetic agents. However, the efficacy of these agents (primarily dexamethasone) when used as single agents for control of emesis has been extensively documented. In addition,

The authors provide a timely introduction to the use of predictive testing as an adjunctive service in the management of a precancerous chronic disease, familial adenomatous polyposis (FAP). As they point out, this new technology carries a significant burden for both the caregiver and affected family since it will alter the genetic counseling process, as well as the clinical recommendations for managing FAP. The unique perspective of registry-based research illustrates the value of generational study of a genetic anomaly over a 22-year-period.

Testing for adenomatous polyposis coli (APC), the gene responsible for familial adenomatous polyposis (FAP), can now be offered to family members in FAP kindreds. With the availability of this test, genetic counseling has become a crucial tool for helping FAP patients and their relatives understand the syndrome and its implications and for assisting at-risk individuals in making informed decisions about whether or not to undergo genetic testing. Genetic counseling can occur at several time points: when FAP is diagnosed, when an FAP patient is considering reproductive options, when a patient is deciding whether to have his or her children screened, and when an at-risk person is considering genetic testing.

PALO ALTO, Calif--New research into the nature of malignant cells deep within the interior of solid tumors suggests a possible explanation as to why tumors with large hypoxic areas tend to be aggressive and treatment resistant.

COLUMBUS, Ohio--Roxane Laboratories and the Roxane Pain Institute have announced two new scholarship programs for health-care professionals in palliative care medicine for cancer and AIDS.

COLLEGEVILLE, PA--Rhône-Poulenc Rorer Inc. and Applied Immune Sciences, Inc. (AIS) have entered into a definitive agreement and plan of merger providing for the acquisition by Rhône-Poulenc Rorer (through its subsidiary RPR Gencell) of AIS at a price of approximately $7.2 million.

SILVER SPRING, Md--The FDA's Antiviral Drugs Advisory Committee took action on three anti-HIV agents at its most recent meeting, recommending approval for Hoffmann-La Roche's protease inhibitor saquinavir (Invirase) and Glaxo Wellcome's 3TC (Epivir) in combination with other AIDS drugs, and favoring a new indication for Bristol-Myers Squibb's stavudine (d4T, Zerit), to treat patients who no longer respond to zidovudine (AZT, Retrovir).

WASHINGTON--A new report by the General Accounting Office (GAO) shows that the Food and Drug Administration now approves drugs twice as fast as it did 6 years ago. In 1987 the FDA took an average of 33 months to approve new drugs, while by 1992 it was taking only 19 months.

MARINA DEL REY, Calif--Clinical researchers must develop strategies to cope with the various obstacles faced by patients and physicians who want to participate in research trials, said oncologists at the Association of Community Cancer Centers (ACCC) economics conference.