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No matter how much education my staff and I participate in, we will never cover every single possible adverse event that an individual may experience. And in some cases, when a patient can't explain their symptoms, we can be at a loss as to how to help them.

This article will describe the historic background of Ra-223; outline the clinical studies which led to phase III trials of this agent; highlight key results of these phase III studies; and explore possible future directions for use of Ra-223 and other alpha particles-both in prostate cancer and for management of other diseases.

Some of the most brilliant physicians I have known have impressed me with their respect for colleagues. They would never express a difference of opinion by denigrating another practitioner, but recent experiences have opened my eyes to the arrogance of some physicians.