Sequencing Strategies in Renal Cell Carcinoma

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Panelists discuss the evolving treatment landscape for renal cell carcinoma beyond the first line, highlighting the importance of personalized sequencing strategies that balance efficacy, safety, and patient quality of life through the use of targeted therapies, immunotherapies, and emerging clinical data.

EP. 1: Overview of the First-Line ccRCC Treatment Landscape

Thomas Hutson, DO, PharmD, PhD, FACP;Moshe Ornstein, MD, MA;Arnab Basu, MBBS;Andrew Hahn, MD

August 29th 2025

Panelists discuss current strategies for first-line treatment sequencing in renal cell carcinoma (RCC), emphasizing immunotherapy-based combinations tailored to disease burden and patient characteristics, while highlighting the importance of multidisciplinary care, real-world experience, and clinical trial data in guiding personalized, patient-centered decisions.

EP. 2: Treatment Management Strategies

Thomas Hutson, DO, PharmD, PhD, FACP;Moshe Ornstein, MD, MA;Arnab Basu, MBBS;Andrew Hahn, MD

August 29th 2025

Panelists discuss the shift toward a more personalized approach in metastatic renal cell carcinoma (RCC) management, highlighting the evolving role of risk stratification, the renewed interest in immune checkpoint inhibitors for favorable-risk patients, and the strategic integration of systemic therapy, active surveillance, and surgical interventions to optimize long-term outcomes.