Campath-1H Monoclonal Antibody in Therapy for Advanced Low-Grade Non-Hodgkin’s Lymphomas: A Phase II Study

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OncologyONCOLOGY Vol 13 No 3
Volume 13
Issue 3

Campath-1H is a humanized anti-CD52 monoclonal antibody (MoAb) that binds to nearly all B-cell and T-cell lymphomas. We report here the results of a multicenter phase II trial of Campath-1H in patients with low-grade NHL. Fifty patients with advanced, heavily pretreated, low-grade NHL were treated with Campath-1H (30 mg administered as a 2-hour intravenous (IV) infusion 3 times weekly for up to 12 weeks).

Campath-1H is a humanized anti-CD52 monoclonal antibody (MoAb) that binds to nearly all B-cell and T-cell lymphomas. We report here the results of a multicenter phase II trial of Campath-1H in patients with low-grade NHL. Fifty patients with advanced, heavily pretreated, low-grade NHL were treated with Campath-1H (30 mg administered as a 2-hour intravenous (IV) infusion 3 times weekly for up to 12 weeks).

Clinical responses were observed in 20% of the patients (2 complete responses [CR), 8 partial responses [PRs]). Lymphoma cells were rapidly eliminated from blood in 16/17 patients (94%). Complete response in bone marrow was obtained in 32% of patients, whereas lymph nodes were normalized in only 5%. Patients with mycosis fungoides appeared to respond often (4/8, including 2 CRs). Lymphopenia occurred in all patients and opportunistic infections were diagnosed in 7. Nine patients had septicemia.

CONCLUSION: Campath-1H had a significant but limited activity in patients with advanced, heavily pretreated NHL. The most pronounced effects were noted in the blood and bone marrow and in patients with mycosis fungoides. The risk for serious infectious complications needs to be considered in severely ill patients. Treatment should be monitored closely, and prophylaxis with cotrimoxazole, acyclovir (Zovirax), and fluconazole (Diflucan) should be given. 

Click here for Dr. Bruce Cheson’s commentary on this abstract.

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Navelbine Increased Elderly Lung Cancer Patients’ Survival
Fludarabine Versus Conventional CVP Chemotherapy in Newly C Diagnosed Patients With Stages III and IV Low-Grade Malignant Non-Hodgkin’s Lymphoma: Preliminary Results From a Prospective, Randomized Phase III Clinical Trial in 381 Patients
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In Vivo Purging and Adjuvant Immunotherapy With Rituximab During PBSC Transplant For NHL
Fludarabine and Cyclophosphamide: A Highly Active and Well-Tolerated Regimen for Patients With Previously Untreated Indolent Lymphomas
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