Opinion|Videos|July 4, 2024

Circulating Tumor DNA Detection Techniques

Author(s)Scott Kopetz, MD, PhD, FACP, Arvind Dasari, MD, MS, Jing Yi, PA

Experts outline circulating tumor (ct) DNA analysis, detailing the two main techniques and their respective advantages and disadvantages.

Episodes in this series

4 KOLs are featured in this panel.

EP. 1 Overview of colorectal cancer and its management

4 KOLs are featured in this panel.

EP. 2 Background on Colorectal Cancer Screening and its Role in Patient Care

4 KOLs are featured in this panel.

EP. 3 Circulating Tumor DNA Detection Techniques

4 KOLs are featured in this panel.

EP. 4 Describing the Value of ctDNA in Clinical Practice

4 KOLs are featured in this panel.

EP. 5 Clinical study of ctDNA-based MRD detection and INTERCEPT program update

4 KOLs are featured in this panel.

EP. 6 Recent findings from BESPOKE

4 KOLs are featured in this panel.

EP. 7 Incorporating ctDNA-Based MRD Testing and Study Findings Into Clinical Practice

4 KOLs are featured in this panel.

EP. 8 Key Considerations for Selection of ctDNA Detection Methods

4 KOLs are featured in this panel.

EP. 9 Clinical Utility of ctDNA Testing

4 KOLs are featured in this panel.

EP. 10 Barriers to Implementing ctDNA Testing

4 KOLs are featured in this panel.

EP. 11 ctDNA Testing in a CRC Clinical Scenario

4 KOLs are featured in this panel.

EP. 12 ctDNA to Inform Adjuvant Therapy and the CIRCULATE Trial

4 KOLs are featured in this panel.

EP. 13 Interpreting and Communicating ctDNA Results

4 KOLs are featured in this panel.

EP. 14 Addressing Gaps in ctDNA Testing

4 KOLs are featured in this panel.

EP. 15 Exploring the Future of ctDNA and Novel Treatment Strategies

Dr Kopetz: Please describe circulating tumor (ct) DNA analysis, highlighting the two primary techniques and the pros and cons of each
1. Tumor-informed techniques (e.g., Signatera and Safe-SeqS)
2. Tumor-agnostic or tumor-naïve techniques (e.g., Guardant Reveal)

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