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Opinion|Videos|July 18, 2024

Incorporating ctDNA-Based MRD Testing and Study Findings Into Clinical Practice

Author(s)Scott Kopetz, MD, PhD, FACP, Arvind Dasari, MD, MS, Jing Yi, PA

Medical experts examine how recent data on circulating tumor DNA-based minimal residual disease testing may impact the clinical management and treatment of colorectal cancer.

Episodes in this series

4 KOLs are featured in this panel.

EP. 1 Overview of colorectal cancer and its management

4 KOLs are featured in this panel.

EP. 2 Background on Colorectal Cancer Screening and its Role in Patient Care

4 KOLs are featured in this panel.

EP. 3 Circulating Tumor DNA Detection Techniques

4 KOLs are featured in this panel.

EP. 4 Describing the Value of ctDNA in Clinical Practice

4 KOLs are featured in this panel.

EP. 5 Clinical study of ctDNA-based MRD detection and INTERCEPT program update

4 KOLs are featured in this panel.

EP. 6 Recent findings from BESPOKE

4 KOLs are featured in this panel.

EP. 7 Incorporating ctDNA-Based MRD Testing and Study Findings Into Clinical Practice

4 KOLs are featured in this panel.

EP. 8 Key Considerations for Selection of ctDNA Detection Methods

4 KOLs are featured in this panel.

EP. 9 Clinical Utility of ctDNA Testing

4 KOLs are featured in this panel.

EP. 10 Barriers to Implementing ctDNA Testing

4 KOLs are featured in this panel.

EP. 11 ctDNA Testing in a CRC Clinical Scenario

4 KOLs are featured in this panel.

EP. 12 ctDNA to Inform Adjuvant Therapy and the CIRCULATE Trial

4 KOLs are featured in this panel.

EP. 13 Interpreting and Communicating ctDNA Results

4 KOLs are featured in this panel.

EP. 14 Addressing Gaps in ctDNA Testing

4 KOLs are featured in this panel.

EP. 15 Exploring the Future of ctDNA and Novel Treatment Strategies

Please discuss the clinical implications of these recent data for the utility of ctDNA-based MRD testing in CRC treatment and management
- Are any of these findings practice-changing?
- Are you routinely testing patients after surgery and after adjuvant therapy on the basis of these data?
What are some barriers to enrollment surrounding MRD testing in CRC for ongoing adjuvant studies (like CIRCULATE)?
- Are patients wanting to escalate or de-escalate treatment?
- How are patients reacting to study testing?

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