First 6 Weeks, Post-Transplant Maintenance, and Co-Mutations

The panelists describe the first 6 weeks for this patient, including twice-weekly labs, weekly EKGs early on, and which checks can be done locally vs at the academic center. The discussion moves to post-transplant maintenance with menin inhibitors, which is not an approved use. One panelist describes selecting patients at higher risk of relapse, such as those who are MRD positive, and the transplant team’s role. The panelists then discuss how DNMT3A and FLT3-ITD co-mutations can signal higher-risk NPM1-mutated disease. Finally, the panelists note that centers use different approaches and highlight the importance of studies to help illuminate the way.