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Opinion|Videos|January 17, 2025

Management of Adverse Events of Special Interest in Patients Receiving CAR -T-Cell Therapy for R/R Multiple Myeloma: Diarrhea, Guillain-Barrée Syndrome, Parkinson’s Disease, and Secondary Malignancies

Author(s)Ajai Chari, MD, Anupama Kumar, MD, Darren Pan, MD

Panelists discuss how challenges in the CAR T referral process include delayed referrals, patient logistics, and managing expectations. One institution addresses these through streamlined communication, patient education, and clear referral guidelines. Community physicians should refer early on, ensure candidacy, and collaborate closely to optimize outcomes.

Episodes in this series

EP. 1 Introduction and CAR-T Therapy in Earlier Lines of Treatment for R/R Multiple Myeloma

EP. 1 Introduction and CAR-T Therapy in Earlier Lines of Treatment for R/R Multiple Myeloma

EP. 2 Decision Points for Using CAR T-Cell Therapy in Early Lines of Treatment

EP. 2 Decision Points for Using CAR T-Cell Therapy in Early Lines of Treatment

EP. 3 Second-Line Treatment for R/R Multiple Myeloma: Who Is the “Right Patient”?

EP. 3 Second-Line Treatment for R/R Multiple Myeloma: Who Is the “Right Patient”?

EP. 4 Referral Process for CAR T-Cell Therapy: Initial Contact Through Patient Evaluation and Selection

EP. 4 Referral Process for CAR T-Cell Therapy: Initial Contact Through Patient Evaluation and Selection

EP. 5 CAR T-Cell Therapy: CAR T-Cell therapy Process and Bridging Therapy

EP. 5 CAR T-Cell Therapy: CAR T-Cell therapy Process and Bridging Therapy

EP. 6 Co-Management and Co-Monitoring of Patients Receiving CAR T-Cell Treatment: Transitions Between the Academic and Community Centers

EP. 6 Co-Management and Co-Monitoring of Patients Receiving CAR T-Cell Treatment: Transitions Between the Academic and Community Centers

EP. 7 Management of Adverse Events of Special Interest in Patients Receiving CAR -T-Cell Therapy for R/R Multiple Myeloma: Diarrhea, Guillain-Barrée Syndrome, Parkinson’s Disease, and Secondary Malignancies

EP. 7 Management of Adverse Events of Special Interest in Patients Receiving CAR -T-Cell Therapy for R/R Multiple Myeloma: Diarrhea, Guillain-Barrée Syndrome, Parkinson’s Disease, and Secondary Malignancies

EP. 8 Example of Successful Collaboration with a Referring Community Practice

EP. 8 Example of Successful Collaboration with a Referring Community Practice

EP. 9 CAR T-Cell Therapy in Multiple Myeloma: Lessons Learned and Key Takeaways

EP. 9 CAR T-Cell Therapy in Multiple Myeloma: Lessons Learned and Key Takeaways

What are the most common challenges you have encountered in the CAR-TCAR T referral process, and how have you addressed them at your institution?
What advice would you provide to community physicians regarding the appropriate timing and preparation for referring patients for CAR-TCAR T-cell therapy?

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Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

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