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Optimizing Treatment for Patients with Relapsed/Refractory Multiple Myeloma : Episode 2

Navigating Treatment Advancements and Recent Approvals in R/R Multiple Myeloma: Expert Insights

June 28, 2024
By Rafael Fonseca, MD
Samer A. Al'Hadidi, MD
  • Naresh Bumma, MD
  • Hans Lee, MD

Opinion
Video

Focusing on recent approvals in earlier lines of relapsed/refractory multiple myeloma, the panel has a comprehensive discussion on the CARTITUDE-4 and KarMMa-3 studies and shares clinical insights on administering CAR T-cell therapy and monitoring patients.

EP: 1.Advancements in the Treatment of Newly Diagnosed MM: Updates from the Phase 3 IMROZ Study

Now Viewing

EP: 2.Navigating Treatment Advancements and Recent Approvals in R/R Multiple Myeloma: Expert Insights

EP: 3.Updates From the Phase 2 MonumenTAL-2 Study Investigating Talquetamab in R/R MM

EP: 4.Long-Term Follow-up with Teclistamab in R/R MM: Updates from MajesTEC-1

EP: 5.Treatment Strategies with Elranatamab in R/R MM: Updates from the MagnetisMM Trials

EP: 6.Expert Perspectives: Sequencing Approaches with CAR-T and Bispecifics in R/R MM

EP: 7.Expert Insights: Strategies for Step-Up Dosing and Long-Term Treatment Management with Bispecifics in R/R MM

EP: 8.The Role of MRD Testing in Guiding Treatment in R/R MM: ASCO 2024 Updates from PERSEUS

EP: 9.Considerations in Sequencing BCMA-Targeting Bispecifics and CAR-T Therapies in R/R MM

EP: 10.Cilta-cel in R/R MM: ASCO 2024 Updates from CARTITUDE Trials

EP: 11.AE Management for CAR-T Therapy: Expert Insights and Perspectives

EP: 12.Looking Ahead: ASCO 2024 Updates and Future Perspectives

EP: 13.Key Takeaways and Clinical Pearls on the Treatment of R/R MM in the Era of Bispecifics

EP: 14.Bispecific Antibodies Are Taking the Multiple Myeloma World by Storm

Video content above is prompted by the following question(s):

  • Focusing on recent approvals in earlier lines of therapy in relapsed/refractory multiple myeloma, discuss the CARTITUDE-4 and KarMMa-3 studies.

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The dual high-affinity binding observed with ISB 2001 may avoid resistance mechanisms reported with other BCMA-targeted therapies.
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MagnetisMM-6 Data Suggest Safety, Manageability of Elranatamab Combo in NDMM

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Results from part 1 dose level G of the MagnetisMM-6 trial found elranatamab, daratumumab, and lenalidomide to be safe and manageable in NDMM.


Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.

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Results from the PERSEUS trial support daratumumab plus bortezomib, lenalidomide, and dexamethasone as a standard of care in transplant-eligible NDMM.


James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.

Exploring the Potential Role of JAK Inhibitors in Multiple Myeloma

James R. Berenson, MD, FACP
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James R. Berenson, MD, describes ongoing efforts to evaluate treatment with JAK inhibitors like ruxolitinib among patients with multiple myeloma.


Subgroup data from CARTITUDE-4 suggest that cilta-cel may overcome the poor prognosis associated with some high-risk features in multiple myeloma.

PFS, OS Improve With Cilta-Cel in R/R Multiple Myeloma Subgroups

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PFS was improved with belantamab mafodotin triplet for patients with relapsed/refractory multiple myeloma with high-risk cytogenetics.

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