Opinion|Videos|July 5, 2024
Long-Term Follow-up with Teclistamab in R/R MM: Updates from MajesTEC-1
Samer Al'Hadidi, MD, provides an overview of recent updates presented at ASCO 2024 from the MajesTEC-1 trial evaluating teclistamab in patients with relapsed/refractory multiple myeloma.
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Video content above is prompted by the following question:
- Please discuss the long-term follow-up from the phase 1/2 MajesTEC-1 study investigating teclistamab in relapsed/refractory multiple myeloma.
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Saad Z. Usmani, MD, MBA, FACP, FASCO, discussed the threshold he will act on in standard-risk disease, and the trial that would make the decision firmer.
In a retrospective analysis, teclistamab produced response rates numerically higher than in MajesTEC-1, with missed doses not compromising outcomes.
Data from the phase 3 OCEAN trial and others support the expanded approval for melflufen in patients with previously treated multiple myeloma.
In a phase 2 trial, CD38-targeted immune-PET detected active multiple myeloma in some patients with no signs of disease on standard fluorodeoxyglucose PET/CT.
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