Prophylactic Cranial Irradiation Improved Survival in Metastatic SCLC

This video examines the results of a retrospective study that compared chemotherapy alone or with prophylactic cranial irradiation in extensive-stage SCLC patients with no brain metastases.

The role of prophylactic cranial irradiation (PCI) in patients with extensive-stage small-cell lung cancer (SCLC) remains controversial, with previous studies reporting conflicting results.

In this video, Sonam Sharma, MD, of the University of Pennsylvania, Philadelphia, discusses results of a National Cancer Database study that looked at metastatic SCLC patients without brain metastases who received either chemotherapy (n = 3,784) or chemotherapy plus PCI (n = 473).

Sharma presented the results of the study (abstract 11) at the 2017 Multidisciplinary Thoracic Cancers Symposium, held March 16–18 in San Francisco.