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Opinion|Videos|January 23, 2025

Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

Author(s)Misako Nagasaka, MD, PhD

Panelist discusses how HER2-directed tumor-agnostic therapies represent an emerging treatment paradigm focused on targeting HER2 mutations regardless of cancer type. Current agents such as trastuzumab deruxtecan show promise across multiple tumor types that express HER2, moving beyond traditional cancer-specific approaches. This precision medicine strategy may expand treatment options and improve outcomes for patients with HER2-altered cancers who previously had limited therapeutic choices.

Episodes in this series

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

Video content above is prompted by the following:

Briefly review the current landscape of HER2-directed tumor-agnostic therapies. What are potential benefits of tumor-agnostic approaches in improving patient outcomes?

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