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Opinion|Videos|January 23, 2025

Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

Author(s)Misako Nagasaka, MD, PhD

Panelist discusses how the DESTINY-Lung02 trial was a dose optimization study where patients with HER2-mutated non–small cell lung cancer (NSCLC) were randomly assigned to a starting dose of 5.4 mg/kg vs 6.4 mg/kg of trastuzumab deruxtecan (T-DXd). DESTINY-Lung03 was a frontline study for HER2 overexpression in NSCLC looking at different combinations of treatment with T-DXd and immunotherapy agents with or without chemotherapy.

Episodes in this series

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

Video content above is prompted by the following:

Review updates and discuss the clinical implications from the following trials:
- DESTINY-Lung02 (Janne PA. 2024 American Society of Clinical Oncology Annual Meeting. Abstract 8543)
- DESTINY-Lung03 part 1 (Planchard D. World Conference on Lung Cancer 2024. Abstract 730)
Please highlight any other trials of note in NSCLC and share your approach to clinical decision-making.

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