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Opinion|Videos|January 23, 2025

HER2 Key Differences and Current Approaches to Biomarker Testing

Author(s)Misako Nagasaka, MD, PhD

Panelist discusses how HER2 testing evaluates protein overexpression, gene amplification, and mutations. Although breast and gastric cancers typically show overexpression/amplification, other tumors more commonly harbor mutations.

Episodes in this series

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 1 Introduction to HER2-Directed Tumor-Agnostic Approaches

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 2 HER2 Key Differences and Current Approaches to Biomarker Testing

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 3 Updates and Clinical Implications of DESTINY-Lung02 and DESTINY-Lung03 Trials

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 4 Review of Current Landscape of HER2-Directed Tumor-Agnostic Therapies

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 5 Influence of DESTINY-PanTumor02 Trials on Trastuzumab Deruxtecan Usage

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

EP. 6 Future of HER2-Directed Tumor-Agnostic Therapies

Video content above is prompted by the following:

What are the key differences between HER2 overexpression, amplification, and mutations across tumor types? How do these differences affect treatment selection?
What is your current approach to biomarker testing for HER2 alterations across different tumor types?

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