Taxotere combination approved for induction therapy in SCCHN

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Oncology NEWS InternationalOncology NEWS International Vol 16 No 10
Volume 16
Issue 10

FDA has approved Sanofi-Aventis' Taxotere (docetaxel) for use in combination with cisplatin and fluorouracil (TPF) for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)

ROCKVILLE, Maryland—FDA has approved Sanofi-Aventis' Taxotere (docetaxel) for use in combination with cisplatin and fluorouracil (TPF) for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).

FDA based its approval on TAX- 324, a multicenter, open-label, randomized trial of 501 patients. Overall survival was significantly prolonged with the Taxotere-containing regimen, compared with PF alone (P = .0058). Median survival was 70.6 months in the TPF group vs 30.1 months in the PF group (HR 0.70).

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BRCA1 overexpression is strongly linked to poor outcome in NSCLC patients treated with cisplatin
Bill aims to 'revitalize' FDA by adding powers and databases
New myeloma trial results; two new studies initiated
Neoadjuvant trastuzumab increases pCR rates
Court rejects right of terminally ill to unproven drugs
Sorafenib improves overall survival in Asian HCC pts
Skipping tam doses increases risk of death
The SGR: The madness behind physician payment fee cuts
Dr. Pegram seeks new breast cancer challenges at Miami
SearchMedica.com receives award
FDA adds survival data to Erbitux product labeling
Colon ca chemo: Sequencing or upfront combinations?
FDA oks Campath as first-line Rx of B-CLL
Merck to donate 3 million doses of Gardasil to poor countries
Remembering Hopkins' Martin D. Abeloff, MD, scientist, educator, leader
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