Navigating Second-Line HR+/HER2- Metastatic Breast Cancer: Focus on PAM (PI3K/AKT/mTOR) Pathway Inhibition

Learn how biomarker testing guides second-line choices after CDK4/6 therapy in HR+ HER2- metastatic breast cancer, including PI3K/AKT/mTOR options.

Learn how liquid and tissue biopsies uncover ESR1 and PI3K mutations to personalize metastatic breast cancer second-line therapy choices.

Explore evolving options for biomarker-negative metastatic breast cancer, from CDK4/6 rechallenge to gadeptolizumab and PAM-pathway targeted therapy.

Clinicians weigh alpelisib’s hyperglycemia, rash, diarrhea and increasingly favor capivasertib for lower glucose risk with close monitoring.

The panel shifts to treatment strategies for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC) who develop an ESR1 mutation after progression on an aromatase inhibitor plus CDK4/6 inhibitor.

The panel explores treatment selection for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC) harboring both ESR1 and PI3K pathway alterations, emphasizing the need to individualize therapy according to disease biology, pace, symptoms, and treatment tolerability.

The panel discusses the patient experience when transitioning between therapies and routes of administration in hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC).

The panel examines how emerging endocrine doublets and earlier biomarker monitoring could reshape treatment sequencing for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC).

The panel examines the VIKTORIA-1 study and its implications for treatment selection in hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC) after CDK4/6 inhibitor therapy.

The panel discusses the clinical and practical considerations surrounding the introduction of gedatolisib for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC), with particular emphasis on its mechanism, toxicity profile, intravenous administration, and patient education.

The panel focuses on multidisciplinary monitoring and proactive toxicity management for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC), particularly as treatment moves into later-line targeted therapy.

The panel applies the treatment framework to clinical scenarios involving patients with hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2− mBC) after progression on first-line CDK4/6 inhibitor plus endocrine therapy.