Carmen J. Allegra, MD

Articles by Carmen J. Allegra, MD

New Antifolates in Clinical Development

ByChris H. Takimoto, MD, PhD,Carmen J. Allegra, MD

July 1st 1995

Numerous new antifolate drugs have been developed in an attempt to overcome the potential mechanisms of tumor cell resistance to methotrexate, which can include decreased drug transport into cells; decreased

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